L-arginine

Two steps

• N-octadecanoylglycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• N-hexadecanoylglycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL3extracellular space, cytosol

• N-dodecanoylglycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• N-decanoylglycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• D-histidineReach from here →
  1. L-Arginine amidinohydrolase
  2. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by ARG1, SLC25A2cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocarnosineReach from here →
  1. transport of arginine and histidine (cytosol to extracellular)
  2. Formation of homocarnosine

  Catalysed by SLC7A5, SLC7A6, CARNS1extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC7A6, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC7A6, DPEP1, DPEP2extracellular space, cytosolOne of 2 routes

• glycyldehydrophenylalanineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC7A6, DPEP1extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. transport of arginine and glutamine (cytosol to extracellular)
  2. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC7A6, PFASextracellular space, cytosol

• kinetensinReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. Chymase

  Catalysed by SLC7A6, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC7A6, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. transport of arginine and threonine (cytosol to extracellular)
  2. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC7A6extracellular space, cytosol

• cholineReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)

  Catalysed by SLC6A14, SLC5A7extracellular space, cytosol

• pyruvateReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC7A6, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 17 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by SLC7A6, TPH1, TPH2extracellular space, cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC7A6, SLC3A2, SLC7A10extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC7A6, GNMTextracellular space, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A6, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. transport of arginine and lysine (cytosol to extracellular)
  2. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. transport of arginine and histidine (cytosol to extracellular)
  2. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC7A5, SLC7A6, CARNS1extracellular space, cytosol

• CHEBI:15765Reach from here →
  1. transport of arginine and tyrosine (cytosol to extracellular)
  2. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC7A6, THextracellular space, cytosolOne of 5 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of arginine and glutamine (cytosol to extracellular)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC7A6, GFPT2, GFPT1extracellular space, cytosol

• sulfateReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A6extracellular space, cytosol

• nitriteReach from here →
  1. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  2. 4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)

  Catalysed by NOS3, NOS1, NOS2, CPcytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC7A6, AGXT2extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. transport of arginine and tyrosine (cytosol to extracellular)
  2. thyroid peroxidase (iodine)

  Catalysed by SLC7A6, TPOextracellular space, cytosolOne of 3 routes

• CHEBI:16523Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC7A6, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. L-Arginine amidinohydrolase
  2. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by ARG1, ACY1cytosol

• 2-phenylacetamideReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC7A6, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A6, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. transport of arginine and methionine (cytosol to extracellular)
  2. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by SLC7A6, MARS1extracellular space, cytosol

• cyanamideReach from here →
  1. L-Arginine amidinohydrolase
  2. urea = cyanamide + H2O

  Catalysed by ARG1, CA1, CA2cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. transport of arginine and methionine (cytosol to extracellular)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC7A6, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of arginine and phenylalanine (cytosol to extracellular)
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLC7A6, CNDP2extracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. transport of arginine and threonine (cytosol to extracellular)
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by SLC7A6, SDS, SDSLextracellular space, cytosol

• tryptamineReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. L-tryptophan decarboxy-lyase

  Catalysed by SLC7A6, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. transport of arginine and glutamine (cytosol to extracellular)
  2. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC7A6, KYAT1extracellular space, cytosolOne of 3 routes

• CHEBI:16856Reach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by SLC7A6, GSSextracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. transport of arginine and glycine (cytosol to extracellular)
  2. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A6, DAOextracellular space, cytosol, peroxisome

• creatineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by GATM, GAMTcytosolOne of 2 routes

• oxalic acidReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC6A14, SLC26A6extracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. L-Arginine amidinohydrolase
  2. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by ARG1, OATcytosol, mitochondrial matrix

• CHEBI:17380Reach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by SLC7A6, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. transport of arginine and proline (cytosol to extracellular)
  2. L-proline:(acceptor) oxidoreductase

  Catalysed by SLC7A6, PRODH2extracellular space, cytosolOne of 2 routes

• AH2Reach from here →
  1. transport of alanine and arginine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC7A6, MOCOSextracellular space, cytosolOne of 4 routes

• S-methyl-5'-thioadenosineReach from here →
  1. Putrescine Export via Putrescine/Arginine Antiporter
  2. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase

  Catalysed by SLC3A2, SLC7A7, SRMextracellular space, cytosolOne of 2 routes