kinetensin

Three steps

• potassium atomReach from here →
  1. Chymase
  2. transport of chloride and leucine (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by CMA1, SLC6A14, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes

• phenylacetylglycineReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by CMA1, SLC7A5, GLYATextracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by CMA1, ACSM4, ACSM1, ACSM2A and 3 moreextracellular space, mitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by CMA1, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, mitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. Chymase
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by CMA1, SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• (2-hydroxyphenyl)acetic acidReach from here →
  1. Chymase
  2. Phenylalanine Transaminase, Mitochondrial
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by CMA1, GOT2, TAT, HPDextracellular space, mitochondrial matrix, cytosol

• CHEBI:28666Reach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by CMA1, SLC7A5extracellular space, cytosol

• CHEBI:28701Reach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by CMA1, ACAA1, SCP2, MYO5Bextracellular space, mitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CMA1, SLC7A5, SCLYextracellular space, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. Chymase
  2. Transport of L-Cystine (L-Leucine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by CMA1, SLC7A9, SLC3A1, CTHextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. Chymase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CMA1, SLC7A9, SLC3A1, NAGSextracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. Chymase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by CMA1, SLC7A9, SLC3A1, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. Chymase
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by CMA1, BCAT2, BCKDHA, BCKDHBextracellular space, mitochondrial matrix

• Cys-tRNA(Cys)Reach from here →
  1. Chymase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A9, SLC3A1, CARS1extracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A5, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. Chymase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A13, DARS1extracellular space, inner side of the membrane, outer side of the membrane, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. Chymase
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A5, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. Chymase
  2. transport of isoleucine and leucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A5, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. Chymase
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A5, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. Chymase
  2. transport of citrulline and leucine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by CMA1, LACC1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. Chymase
  2. transport of asparagine and leucine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A5, NARS1extracellular space, cytosol

• glycocholateReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CMA1, SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. Chymase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by CMA1, SLC7A9, SLC3A1, CTHextracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. Chymase
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by CMA1, SLC7A5, IDO1, TDO2 and 1 moreextracellular space, cytosol

• formic acidReach from here →
  1. Chymase
  2. transport of chloride and leucine (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by CMA1, SLC6A14, SLC26A4extracellular space, cytosolOne of 2 routes

• anthranilic acidReach from here →
  1. Chymase
  2. Transport of L-Kynurenine
  3. L-Kynurenine hydrolase

  Catalysed by CMA1, SLC43A1, KYNUextracellular space, cytosol

• malonic acidReach from here →
  1. Chymase
  2. transport of chloride and leucine (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by CMA1, SLC6A14extracellular space, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. Chymase
  2. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by CMA1, PM20D1extracellular spaceOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Chymase
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by CMA1, PM20D1extracellular space

• D-lysineReach from here →
  1. Chymase
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by CMA1, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. Chymase
  2. transport of arginine and leucine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by CMA1, SLC3A2, SLC7A6, SLC7A7extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. Chymase
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by CMA1, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. Chymase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by CMA1, SLC7A13, CADextracellular space, inner side of the membrane, outer side of the membrane

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. Chymase
  2. transport of leucine and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by CMA1, SLC3A2, SLC7A5, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. Chymase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by CMA1, SLC7A9, SLC3A1, NDUFAB1 and 6 moreextracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. Chymase
  2. transport of isoleucine and leucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by CMA1, SLC7A5, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by CMA1, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by CMA1, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by CMA1, SLC7A5, ALAS1, ALAS2extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. Chymase
  2. transport of isoleucine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by CMA1, SLC7A5, BCAT1extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. Chymase
  2. transport of leucine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by CMA1, SLC7A5, GOT2, GOT1 and 1 moreextracellular space, cytosolOne of 6 routes

• glycochenodeoxycholateReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by CMA1, SLC7A5, BAATextracellular space, cytosol

• glycochenodeoxycholic acidReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CMA1, SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. Chymase
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by CMA1, BCAT2, AADATextracellular space, mitochondrial matrixOne of 13 routes

• 3-hydroxyisovaleric acidReach from here →
  1. Chymase
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. 4-methyl-2-oxopentanoate decarboxylation

  Catalysed by CMA1, BCAT2, ALOX12B, ALOXE3extracellular space, mitochondrial matrix, cytosol

• glycolithocholic acidReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by CMA1, SLC7A5, BAATextracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by CMA1, SLC7A5, GCATextracellular space, cytosol, mitochondrial matrix

• (6R)-L-erythro-6,7-dihydrobiopterinReach from here →
  1. Chymase
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by CMA1, PAH, PCBD1, PCBD2extracellular space

• gamma-Glu-AlaReach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by CMA1, SLC7A5, GGT1, GGT5 and 4 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by CMA1, SLC7A5, GLDC, GCSHextracellular space, cytosol, mitochondrial matrix