N-tetradecanoyl-(2S)-hydroxyglycine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

226 compounds within 3 steps: 4 in 1, 32 in 2, 190 in 3

Three steps

isocitric acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
Catalysed by PAM, CLYBL, SLC25A1mitochondrial matrix, cytosolOne of 3 routes
glutarateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O
3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
Catalysed by PAM, KYAT3, AADAT, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes
cis-aconitic acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
Catalysed by PAM, CLYBL, SLC25A1mitochondrial matrix, cytosolOne of 3 routes
3-oxopropanoateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
Catalysed by PAM, AGXT, AGXT2
thiosulfateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. transport of malate and thiosulfate (cytosol to mitochondria)
Catalysed by PAM, CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes
di-mu-sulfido-diiron(2+)Reach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)
3. De novo synthesis of 2Fe2S
Catalysed by PAM, CYB561D2, CYB561, CYBRD1 and 9 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix
dodecanamideReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
3. N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate
Catalysed by PAM
2-oxohexanoateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
Catalysed by PAM, AGXT2
D-serineReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. D-serine = pyruvate + NH4(+)
Catalysed by PAM, AGXT, AGXT2, SRR
fatty acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. tetradecamide + H2O = tetradecanoate + NH4(+)
3. (10Z)-heptadecenoic acid formation
Catalysed by PAM, FAAHcytosolOne of 4 routes
L-alpha-aminobutyric acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)
Catalysed by PAM, AGXT2, GPTcytosol
5-aminolevulinateReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Catalysed by PAM, GLYATL2, ALAS1, ALAS2
glycochenodeoxycholateReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
Catalysed by PAM, GLYATL2, BAAT
glycochenodeoxycholic acidReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by PAM, GLYATL2, BAATperoxisomeOne of 3 routes
3-hydroxyisovaleric acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine
3. 4-methyl-2-oxopentanoate decarboxylation
Catalysed by PAM, AADAT, ALOX12B, ALOXE3cytosol
glycolithocholic acidReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by PAM, GLYATL2, BAATcytosolOne of 2 routes
decanamideReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
3. N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate
Catalysed by PAM
L-2-amino-3-oxobutanoic acidReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by PAM, GLYATL2, GCATmitochondrial matrix
(R)-lactic acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. (R)-Lactate:NAD+ oxidoreductase
Catalysed by PAM, AGXT, AGXT2, LDHDcytosol
(S)-lactic acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. (S)-Lactate:NAD+ oxidoreductase
Catalysed by PAM, AGXT, AGXT2, LDHB and 1 moremitochondrial matrixOne of 5 routes
2-iminopropanoateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. 2-iminopropanoate + H2O = pyruvate + NH4(+)
Catalysed by PAM, AGXT, AGXT2, RIDA
phosphoenolpyruvic acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. pyruvate kinase (dTDP)
Catalysed by PAM, AGXT, AGXT2, PKM and 1 morecytosol
N-acetyl-beta-neuraminic acidReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by PAM, AGXT, AGXT2, NPLcytosol
L-ornithineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. L-Arginine:glycine amidinotransferase
Catalysed by PAM, GLYATL2, GATMcytosolOne of 7 routes
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
Catalysed by PAM, AADAT, ADI1
S(8)-aminomethyldihydrolipoamideReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by PAM, GLYATL2, GLDC, GCSHmitochondrial matrix
a 3-acylpyruvateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
Catalysed by PAM, AGXT, AGXT2, FAHD1
(S)-malyl-CoAReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate
Catalysed by PAM, CLYBL, SUCLG1, SUCLA2
3-oxohexadecanoyl-CoAReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA
Catalysed by PAM, GLYATL2, ELOVL6, ELOVL3
dodecanoyl-CoAReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. Fatty Acid Beta Oxidation (C14->C12), Mitochondrial
Catalysed by PAM, GLYATL2, HADHA, ACADVL and 1 moremitochondrial matrixOne of 2 routes
propanoyl-CoAReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by PAM, CLYBL
sarcosineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by PAM, GLYATL2, PIPOXOne of 2 routes
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by PAM, GLYATL2, SHMT1, SHMT2
an N-acylglycineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by PAM, GLYATL2, GLYATL3, GLYAT
2-oxo-3-sulfanylpropanoateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by PAM, AGXT, AGXT2, MPST
2-methyl-3-oxopropanoateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by PAM, AGXT, AGXT2
guanidinoacetateReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. L-Arginine:glycine amidinotransferase
Catalysed by PAM, GLYATL2, GATMcytosolOne of 2 routes
L-methionineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. transport of glycine and methionine (cytosol to extracellular)
Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 8 routes
L-tryptophanReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 7 routes
glutathioneReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by PAM, GLYATL2, GSS
L-threonineReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
3. L-threonine = 2-oxobutanoate + NH4(+)
Catalysed by PAM, AGXT2, SDS, SDSL
L-alanineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)
3. De novo synthesis of 2Fe2S
Catalysed by PAM, CYB561D2, CYB561, CYBRD1 and 9 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 25 routes
leukotriene C4Reach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. leukotriene C4 hydrolysis
Catalysed by PAM, GLYATL2cytosol
L-asparagineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by PAM, GLYATL2extracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 12 routes
L-tyrosineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by PAM, GLYATL2, AADATOne of 3 routes
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by PAM, GLYATL2, AGXT2One of 7 routes
an acyl-CoAReach from here →
1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
3. acyl-CoA pool formation and breakdown
Catalysed by PAM, GLYATL2cytosol
(3S)-citramalyl-CoAReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. glyoxylate + L-alanine = glycine + pyruvate
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by PAM, AGXT, AGXT2, CLYBL
L-2-aminoadipateReach from here →
1. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
Catalysed by PAM, AADAT