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Proteins/UNIPROT:P49447
Transmembrane reductase that probably uses ascorbate as an electron donor to reduce Fe(3+) into Fe(2+) and could play a role in iron transport. It is also able to reduce extracellular monodehydro-L-ascorbate and could be involved in the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides reducing equivalents needed to support the activity of intravesicular enzymes..
Function from UniProtKB (P49447), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of, transported by
1 compound
1 compound.
0 reported routes1 assembled route
119 statements
119 statements · 5 reference databases · Subject: CYB561 · Sources: Bgee, Hetionet, Human Protein Atlas, Rhea, UniProt
2 reactions
Fe(3+)+L-ascorbic acidmonodehydro-L-ascorbate radical+iron(2+)+hydron
Catalysed by CYB561D2 or CYB561 or CYBRD1 or CYB561D1 or CYB561A3
Reaction pageLeft to rightBalanced
Rhea RHEA:30403CC BY 4.0Reference data
monodehydro-L-ascorbate radical+L-ascorbic acidmonodehydro-L-ascorbate radical
2 names
Resolves to: CYB561
Reaction pageLeft to rightBalanced
Rhea RHEA:66524CC BY 4.0Reference data