2,4-dinitrophenyl-S-glutathione

Three steps

• L-leucineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A5extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLCO1B1, GNMTextracellular space, cytosol

• S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheineReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLCO1B1, SLC27A2, ACSL4, ACSL3 and 9 moreextracellular space, cytosol

• CHEBI:15699Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A5extracellular space, cytosolOne of 4 routes

• betaine aldehydeReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. choline dehydrogenase (choline)

  Catalysed by SLCO1B3, BCHE, ACHE, CHDHextracellular space, cytosolOne of 4 routes

• CHEBI:15727Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, NAA10extracellular space, cytosol

• butanalReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  3. butanal + NAD(+) + H2O = butanoate + NADH + 2 H(+)

  Catalysed by SLCO1B1, SLC22A9, ALDH9A1extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:15746Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SAT1 and 1 moreextracellular space, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 14 routes

• malonateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• bromideReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by SLCO1A2, SLCO1B3, MGST3, GSTA4 and 15 moreextracellular space, cytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A6extracellular space, cytosolOne of 2 routes

• a halide anionReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, GSTT4 and 22 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 11-cis-retinolReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLCO1A2, SLCO1B3, AANAT, DGAT1 and 4 moreextracellular space, cytosol

• (R)-carnitineReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-citrullineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A9, SLC3A1, SLC7A6extracellular space, cytosol

• L-valineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A5extracellular space, cytosolOne of 4 routes

• androst-4-ene-3,17-dioneReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase

  Catalysed by SLCO1B1, STS, HSD3B1, HSD3B2extracellular space, cytosol, endoplasmic reticulum

• oxaloacetateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ACLYextracellular space, cytosolOne of 2 routes

• L-arginineReach from here →
  1. transport of histamine (cytosol to extracellular)
  2. L-histidine + H(+) = histamine + CO2
  3. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)

  Catalysed by SLCO1A2, SLCO1B3, HDC, SLC7A6extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• 17beta-estradiolReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. Estrone 3-sulfate sulfohydrolase
  3. Estradiol-17beta:NADP+ 17-oxidoreductase

  Catalysed by SLCO1B1, STS, HSD17B6, HSD17B1 and 5 moreextracellular space, cytosolOne of 5 routes

• CHEBI:16523Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. PROTEIN_BS

  Catalysed by SLCO1B1extracellular space, cytosol

• N(2)-acetyl-L-ornithineReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLCO1B3, BCHE, ACHE, ACY1extracellular space, cytosol

• quinolinic acidReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. Transport of Quinolinic Acid

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC22A6extracellular space, cytosolOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1, CNDP2extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• melatoninReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. S-adenosyl-L-homocysteine:N-acetylserotonin O-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ASMTextracellular space, cytosol

• formaldehydeReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 2 moreextracellular space, cytosolOne of 3 routes

• CHEBI:16857Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 4 routes

• glyoxylic acidReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by SLCO1B1, DAOextracellular space, cytosol, peroxisome

• ferrocytochrome cReach from here →
  1. transport of prostaglandin A2 (cytosol to extracellular)
  2. Transport of Prostaglandin A2, Lactate Antiport
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by SLCO1B1, CYB5D1extracellular space, cytosol, mitochondrial matrix

• oxalic acidReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC26A6extracellular space, cytosol

• (R)-3-hydroxybutyric acidReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. transport of (R)-3-hydroxybutanoate and acetate (cytosol to extracellular)

  Catalysed by SLCO1B3, BCHE, ACHE, SLC16A4 and 3 moreextracellular space, cytosolOne of 4 routes

• 17alpha-estradiolReach from here →
  1. transport of estrone 3-sulfate (cytosol to extracellular)
  2. Estrone 3-sulfate sulfohydrolase
  3. 17alpha-estradiol + NADP(+) = estrone + NADPH + H(+)

  Catalysed by SLCO1B1, STS, DHRS1extracellular space, cytosol

• L-isoleucineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by SLCO1B1, SLC7A5, SLC7A6extracellular space, cytosolOne of 2 routes

• CHEBI:17208Reach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 19 routes

• homocysteineReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. Formation of Homocystine

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosol

• itaconateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24, SUGCTextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 17alpha-hydroxyprogesteroneReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by SLCO1B3, BCHE, ACHE, CYP17A1extracellular space, cytosol, endoplasmic reticulum

• anilineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLCO1A2, SLCO1B3, AANAT, NAT2 and 1 moreextracellular space, cytosol

• CHEBI:17312Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLCO1A2, SLCO1B3, AANATextracellular space, cytosolOne of 2 routes

• 3-hydroxy-3-methylglutarateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24, SUGCTextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• all-trans-retinolReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosol

• linoleic acidReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 14 routes

• sulfiteReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, TSTD1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• D-aspartic acidReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4, SLC1A7 and 4 moreextracellular space, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. Utilized Transport
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SLCO1B1, CPT2, CPT1Aextracellular space, cytosol, endoplasmic reticulum, peroxisomeOne of 10 routes

• AH2Reach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. choline + A = betaine aldehyde + AH2

  Catalysed by SLCO1B3, BCHE, ACHE, CHDHextracellular space, cytosolOne of 20 routes

• 5-aminolevulinic acidReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by SLCO1B1, ALAS1, ALAS2, CPNE7extracellular space, cytosol, mitochondrial matrix