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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P22303

ACHE

Protein·UNIPROT:P22303Acetylcholinesterase1 finding

Open in the graph

Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis..

Function from UniProtKB (P22303), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

Findings that name it directly

sodium benzoateactivatesInsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

38 statements

38 statements · 7 reference databases · Subject: ACHE · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

ACHE covaries with BRI3ProteinHetionet hetionet:covaries:25798-43Inferred only
ACHE covaries with CR2ProteinHetionet hetionet:covaries:1380-43Inferred only
ACHE covaries with LARP6ProteinHetionet hetionet:covaries:43-55323Inferred only
ACHE covaries with MANSC1ProteinHetionet hetionet:covaries:43-54682Inferred only
ACHE covaries with MDFIProteinHetionet hetionet:covaries:4188-43Inferred only
ACHE covaries with NGFRProteinHetionet hetionet:covaries:43-4804Inferred only
ACHE covaries with NYAP1ProteinHetionet hetionet:covaries:222950-43Inferred only
ACHE covaries with THADAProteinHetionet hetionet:covaries:43-63892Inferred only
ACHE is expressed in hindlimb stylopod muscleAnatomyBgee ENSG00000087085Inferred only
ACHE is expressed in right hemisphere of cerebellumAnatomyBgee ENSG00000087085Inferred only
ACHE interacts with APPProteinHetionet hetionet:interacts:351-43Inferred only
ACHE interacts with COLQProteinHetionet hetionet:interacts:43-8292Inferred only

Show the remaining 26

ACHE interacts with ENO1ProteinHetionet hetionet:interacts:2023-43Inferred only
ACHE interacts with JUNProteinHetionet hetionet:interacts:3725-43Inferred only
ACHE interacts with RACK1ProteinHetionet hetionet:interacts:10399-43Inferred only
ACHE participates in Acetylcholine synthesisPathwayWikiPathways WP528Inferred only
ACHE participates in Biogenic amine synthesisPathwayWikiPathways WP550Inferred only
ACHE participates in Burn wound healingPathwayWikiPathways WP5055Inferred only
ACHE participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
ACHE participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
ACHE participates in Melatonin metabolism and effectsPathwayWikiPathways WP3298Inferred only
ACHE participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ACHE participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ACHE participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
ACHE participates in Monoamine transport and regulationPathwayWikiPathways WP727Inferred only
ACHE participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
ACHE participates in Neurotransmitter clearancePathwayReactome R-HSA-112311Inferred only
ACHE participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only
ACHE participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
ACHE participates in Synthesis of PCPathwayReactome R-HSA-1483191Inferred only
ACHE participates in Synthesis, secretion, and deacylation of GhrelinPathwayReactome R-HSA-422085Inferred only
ACHE participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
ACHE regulates negative regulation of synaptic transmission, cholinergicBiological processgene ontology P22303|GO:0032223Inferred only
ACHE regulates positive regulation of cold-induced thermogenesisBiological processgene ontology P22303|GO:0120162Inferred only
ACHE regulates positive regulation of protein secretionBiological processgene ontology P22303|GO:0050714Inferred only
acetylcholine is a substrate of ACHECompoundHuman-GEM MAR08421Inferred only
acetylcholine is a substrate of ACHECompoundRhea RHEA:17561Inferred only
acetylcholine is a substrate of ACHECompoundHuman-GEM MAR00641Inferred only

Reactions

3 reactions

acetylcholine+wateracetate+choline+proton
Catalysed by ACHE or BCHE
Reaction pageLeft to rightBalancedEC 3.1.1.7, 3.1.1.8cytosol
Human-GEM MAR00641CC BY 4.0Reference data
acetylcholine+wateracetate+choline+proton
Catalysed by ACHE

Sources cited

1 paper

Subject: ACHE
Findings: 1
Papers: 1

Sodium benzoate induces neurobehavioral deficits and brain oxido-inflammatory stress in male Wistar rats: Ameliorative role of ascorbic acid.record2022PMID:351877461 finding

← Every protein Find it in the graph →

or BCHE

Reaction pageLeft to rightBalancedEC 3.1.1.7, 3.1.1.8extracellular space

Human-GEM MAR08421CC BY 4.0Reference data

acetylcholine+watercholine+acetate+hydron

Catalysed by ACHE

Reaction pageLeft to rightBalanced

Rhea RHEA:17561CC BY 4.0Reference data