an N(2)-acyl-L-glutamine

Three steps

• kinetensinReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GLYATL2extracellular space, cytosol

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by GLYATL1B, GLYATL1, LPCAT3cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by GLYATL1B, GLYATL1, GLYATL2cytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by GLYATL1B, GLYATL1, SOAT1cytosol

• acetaldehydeReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:15345Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 3 moremitochondrial matrix, cytosolOne of 2 routes

• cholineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 3 moremitochondrial matrix, nucleusOne of 10 routes

• pyruvateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GLYATL1B, GLYATL1, KYAT1, AGXT2cytosol, mitochondrial matrixOne of 18 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, TPH1 and 1 moreextracellular space, cytosolOne of 3 routes

• CHEBI:15380Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 4 moremitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 4 moremitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 3 moremitochondrial matrix

• isovaleryl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 4 moremitochondrial matrixOne of 3 routes

• CHEBI:15519Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrix, peroxisomeOne of 2 routes

• phenylacetyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 2 moremitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 5 moremitochondrial matrix, cytosolOne of 46 routes

• CHEBI:15611Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, GNMTextracellular space, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, TPH1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:15650Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 34 moremitochondrial matrix, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 3 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Palmitoyl-CoA hydrolase

  Catalysed by GLYATL1B, GLYATL1, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, THextracellular space, cytosolOne of 5 routes

• 1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. plasmenylethanolamine 2-acylhydrolase

  Catalysed by GLYATL1B, GLYATL1, LPCAT4, LPCAT3 and 20 morecytosol

• N-carbamoyl-L-aspartic acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by GLYATL1B, GLYATL1, CADcytosolOne of 2 routes

• keto-D-fructose 6-phosphateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)

  Catalysed by GLYATL1B, GLYATL1, GFPT2, GFPT1 and 2 morecytosol

• thioredoxin dithiolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by GLYATL1B, GLYATL1, QARS1cytosolOne of 2 routes

• cholesterolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. an acyl-CoA + cholesterol = a cholesterol ester + CoA
  3. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

  Catalysed by GLYATL1B, GLYATL1, SOAT2, SOAT1 and 4 more

• hexadecan-1-olReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by GLYATL1B, GLYATL1, FAR1, FAR2cytosol, peroxisome

• sulfateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by GLYATL1B, GLYATL1, SLC6A14, SLC26A6extracellular space, cytosolOne of 3 routes

• ureaReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• 11-cis-retinyl hexadecanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GLYATL1B, GLYATL1, DGAT1, LRAT and 3 morecytosol

• L-cystineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SLC7A9 and 1 morecytosol, extracellular spaceOne of 9 routes

• 11-cis-retinolReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 7 moremitochondrial matrix, cytosolOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GLYATL1B, GLYATL1, KYAT1, AGXT2cytosol, mitochondrial matrix

• iodideReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, TPOextracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by GLYATL1B, GLYATL1, GPAT3, GPAT2 and 3 moremitochondrial matrix, cytosolOne of 6 routes

• nitric oxideReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, NOS3 and 2 moreextracellular space, cytosolOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by GLYATL1B, GLYATL1, SLC7A6, ACY1extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, EPXextracellular space, cytosol

• CHEBI:16566Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. sphingosine N-acyltransferase (sphinganine)
  3. N-acylsphingosine amidohydrolase

  Catalysed by GLYATL1B, GLYATL1, CERS1, CERS6 and 9 morecytosol

• D-alanyl-D-alanineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of D-alanine and glutamine (cytosol to extracellular)
  3. Formation of Alanylalanine

  Catalysed by GLYATL1B, GLYATL1, SLC3A2, SLC7A10extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. L-Glutamine:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GLYATL1B, GLYATL1, KYAT1, SCLYcytosol

• Met-tRNA(Met)Reach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, MARS1extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, AADATextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by GLYATL1B, GLYATL1, SLC7A5, CNDP2extracellular space, cytosol