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Proteins/UNIPROT:P27544
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (By similarity). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (By similarity). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria..
Function from UniProtKB (P27544), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
59 statements
59 statements · 8 reference databases · Subject: CERS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
11 reactions
CHEBI:16566+an acyl-CoACHEBI:1146900+an N-acylsphinganine+proton
Catalysed by CERS4 or CERS5 or CERS2 or CERS3 or CERS6 or CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00750CC BY 4.0Reference data
9 names
Resolves to: CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00758CC BY 4.0Reference data
sphing-4-enine+a fatty acyl-CoAan N-acylsphing-4-enine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23768CC BY 4.0Reference data
a fatty acyl-CoA+sphinganinean N-acylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS5 or CERS4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:34735CC BY 4.0Reference data
sphinganine+octadecanoyl-CoAN-(octadecanoyl)-sphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36547CC BY 4.0Reference data
eicosanoyl-CoA+sphinganineN-eicosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36555CC BY 4.0Reference data
2-hydroxyoctadecanoyl-CoA+sphinganineN-(2-hydroxyoctadecanoyl)-sphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:36615CC BY 4.0Reference data
sphing-4-enine+octadecanoyl-CoAN-octadecanoylsphing-4-enine+coenzyme A(4-)+hydron
Catalysed by CERS1 or TLCD3B or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36691CC BY 4.0Reference data
hexadecasphinganine+octadecanoyl-CoAN-octadecanoylhexadecasphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:43044CC BY 4.0Reference data
a sphingoid base+octadecanoyl-CoAan N-octadecanoyl-sphingoid base+coenzyme A(4-)+hydron
Catalysed by CERS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:61476CC BY 4.0Reference data
heptadecasphing-4-enine+octadecanoyl-CoAN-octadecanoyl-heptadecasphing-4-enine+coenzyme A(4-)+hydron
Catalysed by CERS1
Reaction pageLeft to rightBalanced
Rhea RHEA:67596CC BY 4.0Reference data