Compound
CHEBI:16566
A 2-aminooctadecane-1,3-diol having (2S,3R)-configuration.
Definition from ChEBI (CHEBI:16566), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
14 entities
14 entities reached.
0 reported hops14 assembled from the scaffold
- SPHK1ProteinUNIPROT:Q9NYA1substrate ofInferred only31 paths31 endpoints
- ASAH1ProteinUNIPROT:Q13510substrate ofInferred only26 paths26 endpoints
- SPHK2ProteinUNIPROT:Q9NRA0substrate ofInferred only22 paths11 endpoints
- DBPProteinUNIPROT:Q10586substrate ofInferred only12 paths12 endpoints
- CERS3ProteinUNIPROT:Q8IU89substrate ofInferred only9 paths9 endpoints
- CERS2ProteinUNIPROT:Q96G23substrate ofInferred only9 paths9 endpoints
- CERS4ProteinUNIPROT:Q9HA82substrate ofInferred only9 paths9 endpoints
- CERS1ProteinUNIPROT:P27544substrate ofInferred only8 paths8 endpoints
- CERS6ProteinUNIPROT:Q6ZMG9substrate ofInferred only8 paths8 endpoints
- CERS5ProteinUNIPROT:Q8N5B7substrate ofInferred only7 paths7 endpoints
- ASAH2ProteinUNIPROT:Q9NR71substrate ofInferred only7 paths7 endpoints
- ACER1ProteinUNIPROT:Q8TDN7substrate ofInferred only5 paths5 endpoints
What the reference databases state
Chemical structure
- an N-acylsphinganine has the functional parent CHEBI:16566CompoundChEBI CHEBI:31488Inferred only
- an N-acylsphinganine-1-phosphocholine has the functional parent CHEBI:16566CompoundChEBI CHEBI:67090Inferred only
- N-(2-hydroxytetracosanoyl)-sphinganine has the functional parent CHEBI:16566CompoundChEBI CHEBI:52371Inferred only
- N-hexacosanoylsphinganine has the functional parent CHEBI:16566CompoundChEBI CHEBI:52962Inferred only
Statements
20 statements
20 statements · 1 reference database · Subject: CHEBI:16566 · Sources: Human-GEM
- 3-oxosphinganine is converted to CHEBI:16566CompoundHuman-GEM MAR00741Inferred only
- CHEBI:16566 is converted to sphinganine 1-phosphateCompoundHuman-GEM MAR12083Inferred only
- sphinganine 1-phosphate is converted to CHEBI:16566CompoundHuman-GEM MAR08233Inferred only
- sphinganine 1-phosphate is converted to CHEBI:16566CompoundHuman-GEM MAR00746Inferred only
- CHEBI:16566 is converted to sphinganine 1-phosphateCompoundHuman-GEM MAR00744Inferred only
- CHEBI:16566 is a substrate of ACER1ProteinHuman-GEM MAR00753Inferred only
- CHEBI:16566 is a substrate of ACER2ProteinHuman-GEM MAR00753Inferred only
- CHEBI:16566 is a substrate of ACER3ProteinHuman-GEM MAR00753Inferred only
- CHEBI:16566 is a substrate of ASAH1ProteinHuman-GEM MAR00753Inferred only
- CHEBI:16566 is a substrate of ASAH2ProteinHuman-GEM MAR00753Inferred only
- CHEBI:16566 is a substrate of CERS1ProteinHuman-GEM MAR00750Inferred only
- CHEBI:16566 is a substrate of CERS2ProteinHuman-GEM MAR00750Inferred only
Show the remaining 8
- CHEBI:16566 is a substrate of CERS3ProteinHuman-GEM MAR00750Inferred only
- CHEBI:16566 is a substrate of CERS4ProteinHuman-GEM MAR00750Inferred only
- CHEBI:16566 is a substrate of CERS5ProteinHuman-GEM MAR00750Inferred only
- CHEBI:16566 is a substrate of CERS6ProteinHuman-GEM MAR00750Inferred only
- CHEBI:16566 is a substrate of DBPProteinHuman-GEM MAR00744Inferred only
- CHEBI:16566 is a substrate of SPHK1ProteinHuman-GEM MAR00744Inferred only
- CHEBI:16566 is a substrate of SPHK2ProteinHuman-GEM MAR00744Inferred only
- CHEBI:16566 is a substrate of SPHK2ProteinHuman-GEM MAR12083Inferred only
Reactions
18 reactions
3-oxosphinganine+proton+NADPH(4-)NADP(3-)+CHEBI:16566
Catalysed by KDSR
Reaction pageLeft to rightBalancedEC 1.1.1.102cytosol
Human-GEM MAR00741CC BY 4.0Reference data
ATP+CHEBI:16566ADP+proton+sphinganine 1-phosphate
Catalysed by SPHK2 or DBP or SPHK1
Reaction pageLeft to rightBalancedEC 2.7.1.91cytosol
Human-GEM MAR00744CC BY 4.0Reference data
water+sphinganine 1-phosphatephosphate(3-)+CHEBI:16566
Catalysed by PLPP1 or PLPP2 or PLPP3
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR00746CC BY 4.0Reference data
CHEBI:16566+an acyl-CoACHEBI:1146900+an N-acylsphinganine+proton
Catalysed by CERS4 or CERS5 or CERS2 or CERS3 or CERS6 or CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00750CC BY 4.0Reference data
an N-acylsphinganine+waterCHEBI:16566+fatty acid
Catalysed by ACER3 or ASAH1 or ACER1 or ACER2 or ASAH2
Reaction pageReversibleBalance undeterminableEC 3.5.1.23cytosol
Human-GEM MAR00753CC BY 4.0Reference data
water+sphinganine 1-phosphatephosphate(3-)+CHEBI:16566
Catalysed by SGPP1
Reaction pageLeft to rightBalancedEC 3.1.3.-endoplasmic reticulum
Human-GEM MAR08233CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR08737CC BY 4.0Reference data
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR11958CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11959CC BY 4.0Reference data
ATP+CHEBI:16566ADP+proton+sphinganine 1-phosphate
Catalysed by SPHK2
Reaction pageLeft to rightBalancedEC 2.7.1.91nucleus
Human-GEM MAR12083CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR12100CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, Golgi apparatus
Human-GEM MAR12101CC BY 4.0Reference data
Other names
14 names
Resolves to: CHEBI:16566
- Also called
- (2S,3R)-2-amino-1,3-octadecanediol(2S,3R)-2-aminooctadecane-1,3-diol(R-(R*,S*))-2-aminooctadecane-1,3-diol2-Amino-1,3-dihydroxyoctadecaneC18-dihydrosphingosineC18-sphinganineD-erythro-1,3-dihydroxy-2-aminooctadecaneD-erythro-2-amino-1,3-octadecanediolD-erythro-C18-dihydrosphingosined18:0DihydrosphingosineoctadecasphinganineSafingolSphinganine