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Proteins/UNIPROT:Q96K12
Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (FAls). A lower activity can be observed with shorter fatty acyl-CoA substrates. Can produce very long-chain and ultra long-chain FAls, regardless of whether they have a straight or branched chain. Involved in the production of ether lipids/plasmalogens and wax monoesters whose synthesis requires FAls as substrates..
Function from UniProtKB (Q96K12), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 6 reference databases · Subject: FAR2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
17 reactions
2proton+2NADPH(4-)+palmitoyl-CoACHEBI:1146900+hexadecan-1-ol+2NADP(3-)
Reaction pageLeft to rightBalancedEC 1.17.1.9peroxisome
Human-GEM MAR00703CC BY 4.0Reference data
2 names
Resolves to: FAR2
Reaction pageLeft to rightBalance undeterminableEC 1.2.1.84peroxisome
Human-GEM MAR10061CC BY 4.0Reference data
hexadecanoyl-CoA+2NADPH(4-)+2hydronhexadecan-1-ol+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:36315CC BY 4.0Reference data
octadecanoyl-CoA+2NADPH(4-)+2hydronoctadecan-1-ol+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:36319CC BY 4.0Reference data
a long-chain fatty acyl-CoA+2NADPH(4-)+2hydronCHEBI:77396+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52716CC BY 4.0Reference data
eicosanoyl-CoA+2NADPH(4-)+2hydroneicosan-1-ol+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:81727CC BY 4.0Reference data
docosanoyl-CoA+2NADPH(4-)+2hydrondocosan-1-ol+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR2
Reaction pageLeft to rightBalanced
Rhea RHEA:81731CC BY 4.0Reference data
tetracosanoyl-CoA+2NADPH(4-)+2hydrontetracosan-1-ol+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR2
Reaction pageLeft to rightBalanced
Rhea RHEA:81735CC BY 4.0Reference data
hexacosanoyl-CoA+2NADPH(4-)+2hydronhexacosan-1-ol+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR2
Reaction pageLeft to rightBalanced
Rhea RHEA:81739CC BY 4.0Reference data
octacosanoyl-CoA+2NADPH(4-)+2hydronCHEBI:28243+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR2
Reaction pageLeft to rightBalanced
Rhea RHEA:81743CC BY 4.0Reference data
triacontanoyl-CoA+2NADPH(4-)+2hydronCHEBI:28409+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR2
Reaction pageLeft to rightBalanced
Rhea RHEA:81747CC BY 4.0Reference data
a very long-chain fatty acyl-CoA+2NADPH(4-)+2hydronCHEBI:138741+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:81751CC BY 4.0Reference data