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Proteins/UNIPROT:Q8WVX9
Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity)..
Function from UniProtKB (Q8WVX9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
43 statements
43 statements · 6 reference databases · Subject: FAR1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
2proton+2NADPH(4-)+palmitoyl-CoACHEBI:1146900+hexadecan-1-ol+2NADP(3-)
Reaction pageLeft to rightBalancedEC 1.17.1.9peroxisome
Human-GEM MAR00703CC BY 4.0Reference data
2 names
Resolves to: FAR1
Catalysed by FAR1
Reaction pageLeft to rightBalancedEC 1.2.1.-cytosol
Human-GEM MAR06953CC BY 4.0Reference data
water+NAD(+)+MAM02922c2proton+MAM02188c+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.2.1.-cytosol
Human-GEM MAR06954CC BY 4.0Reference data
2proton+NADH(2-)+MAM02919cwater+NAD(+)+spermine monoaldehyde
Reaction pageReversibleBalancedEC 1.2.1.-cytosol
Human-GEM MAR06973CC BY 4.0Reference data
2proton+2NADPH(4-)+an acyl-CoACHEBI:1146900+2NADP(3-)+MAM03417x
Reaction pageLeft to rightBalance undeterminableEC 1.2.1.84peroxisome
Human-GEM MAR10061CC BY 4.0Reference data
hexadecanoyl-CoA+2NADPH(4-)+2hydronhexadecan-1-ol+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:36315CC BY 4.0Reference data
octadecanoyl-CoA+2NADPH(4-)+2hydronoctadecan-1-ol+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:36319CC BY 4.0Reference data
(9Z)-octadecenoyl-CoA+2NADPH(4-)+2hydron(9Z)-octadecen-1-ol+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR1
Reaction pageLeft to rightBalanced
Rhea RHEA:36323CC BY 4.0Reference data
(9Z,12Z)-octadecadienoyl-CoA+2NADPH(4-)+2hydron(9Z,12Z)-octadecadien-1-ol+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR1
Reaction pageLeft to rightBalanced
Rhea RHEA:36363CC BY 4.0Reference data
a long-chain fatty acyl-CoA+2NADPH(4-)+2hydronCHEBI:77396+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52716CC BY 4.0Reference data
eicosanoyl-CoA+2NADPH(4-)+2hydroneicosan-1-ol+2NADP(3-)+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:81727CC BY 4.0Reference data
CHEBI:231998+2NADPH(4-)+2hydronCHEBI:84911+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR1
Reaction pageLeft to rightBalanced
Rhea RHEA:81763CC BY 4.0Reference data