(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA

Three steps

• acetylcholineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by BAAT, ACOT6, CHATcytosol, nucleusOne of 3 routes

• pyruvateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by BAAT, ACOT6, AGXT2cytosol, mitochondrial matrixOne of 20 routes

• CHEBI:15467Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by BAAT, ACOT6, AACS, HMGCS1cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. ATP citrate lyase (citrate)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by BAAT, ACOT6, ACLYcytosol, mitochondrial matrixOne of 5 routes

• L-leucineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 21 routes

• (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 3 moreperoxisome, cytosol

• CHEBI:15611Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix

• (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 3 moreperoxisome, cytosol

• CHEBI:15699Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 17 routes

• betaine aldehydeReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. choline dehydrogenase (choline)

  Catalysed by BAAT, ACOT6, CHAT, CHDHcytosol, nucleusOne of 3 routes

• trimethylenediamineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by BAAT, ACOT6, SAT1, SAT2 and 1 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosol, endoplasmic reticulumOne of 4 routes

• 1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. plasmenylethanolamine 2-acylhydrolase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1 and 18 morecytosol

• CHEBI:15971Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 11 routes

• 11-cis-retinalReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol:NAD+ oxidoreductase

  Catalysed by BAAT, ACOT6, DGAT1, LRAT and 10 morecytosolOne of 4 routes

• cholesterolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + cholesterol = a cholesterol ester + CoA
  3. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

  Catalysed by SOAT2, SOAT1, CES1, LIPN and 2 morecytosol

• hexadecan-1-olReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. formate dehydrogenase (palmitoyl-CoA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 8 morecytosol, peroxisome

• 11-cis-retinyl hexadecanoateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 11 morecytosolOne of 6 routes

• L-cystineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by BAAT, ACOT6, SLC7A9, SLC3A1cytosol, mitochondrial matrix, extracellular spaceOne of 5 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by BAAT, ACOT6, AGXT2cytosol, mitochondrial matrix

• L-citrullineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• L-valineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• L-arginineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:16523Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. PROTEIN_BS

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 5 routes

• CHEBI:16566Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphingosine N-acyltransferase (sphinganine)
  3. N-acylsphingosine amidohydrolase

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 7 morecytosol

• CHEBI:16633Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by BAAT, ACOT6, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by BAAT, ACOT6, NAGS, MARS1cytosol, mitochondrial matrix

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by BAAT, ACOT6, NAGS, AADATcytosol, mitochondrial matrix

• 2-oxobutanoateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-cystathionine cysteine-lyase (deaminating

  Catalysed by BAAT, ACOT6, NAGS, CTHcytosol, mitochondrial matrixOne of 2 routes

• CHEBI:16856Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, ZDHHC11B, NAA10 and 31 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:16857Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 4 morecytosol, mitochondrial matrix, extracellular spaceOne of 19 routes

• pantetheine 4'-phosphateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)
  3. Dephospho-CoA nucleotidohydrolase

  Catalysed by BAAT, ACOT6, ACP2, ENPP3 and 1 morecytosol, lysosomeOne of 2 routes

• psychosineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. UDP-alpha-D-galactose:sphingosine 1-beta-galactosyltransferase

  Catalysed by BAAT, ACOT6, ASAH1, ACER2 and 2 morecytosol, Golgi apparatus

• glyoxylic acidReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, peroxisome

• taurolithocholateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. bile acid-CoA:amino acid N-acyltransferase (lithocholate)

  Catalysed by BAAT, ACOT6cytosolOne of 2 routes

• L-isoleucineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 18 routes

• CHEBI:17203Reach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 15 routes

• S-(4,8-dimethylnonanoyl)-4'-phosphopantetheineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
  3. 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, CRAT, CROT and 1 morecytosol, peroxisome

• S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• S-(9Z-hexadecenoyl)-4'-phosphopantetheineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• itaconateReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by BAAT, ACOT6, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 4 routes

• N-octadecanoyl-heptadecasphing-4-enineReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. heptadecasphing-4-enine + octadecanoyl-CoA = N-octadecanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosol

• myo-inositolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
  3. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)

  Catalysed by LCLAT1, MBOAT7, CDIPTcytosol

• all-trans-retinolReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by BAAT, ACOT6, DGAT1, LRAT and 3 morecytosolOne of 4 routes

• linoleic acidReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• a 2-acylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  3. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)

  Catalysed by MOGAT2, AWAT2, MOGAT1, DAGLB and 2 morecytosol

• a monoacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  3. 1,2-diacyl-sn-glycerol acylhydrolase

  Catalysed by MOGAT2, AWAT2, MOGAT1, LIPF and 14 morecytosol, extracellular spaceOne of 8 routes