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Proteins/UNIPROT:Q96PD6

MOGAT1

Protein·UNIPROT:Q96PD62-acylglycerol O-acyltransferase 1

Open in the graph

Involved in glycerolipid synthesis and lipid metabolism. Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn-1 or sn-3 positions. It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1-acyl-sn-glycerol) equally well as substrates, and uses sn-3-monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency. Probably not involved in absorption of dietary fat in the small intestine..

Function from UniProtKB (Q96PD6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

69 statements

69 statements · 4 reference databases · Subject: MOGAT1 · Sources: Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

MOGAT1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
MOGAT1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
MOGAT1 participates in Triacylglyceride synthesisPathwayWikiPathways WP325Inferred only
MOGAT1 participates in Triglyceride biosynthesisPathwayReactome R-HSA-75109Inferred only
MOGAT1 participates in Triglyceride metabolismPathwayReactome R-HSA-8979227Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77547Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77291Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77591Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77587Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:39951Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77267Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77583Inferred only

Show the remaining 57

(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77563Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:37915Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:38115Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:38119Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:38123Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:38131Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:38135Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:38139Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77551Inferred only
(9Z)-octadecenoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77595Inferred only
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:38139Inferred only
1-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:37915Inferred only
1-(9Z-octadecenoyl)-sn-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77267Inferred only
1-(9Z,12Z-octadecadienoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:38131Inferred only
1-(9Z,12Z-octadecadienoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77591Inferred only
1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:38135Inferred only
1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77595Inferred only
1-dodecanoylglycerol is a substrate of MOGAT1CompoundRhea RHEA:77587Inferred only
1-dodecanoylglycerol is a substrate of MOGAT1CompoundRhea RHEA:38115Inferred only
1-hexadecanoylglycerol is a substrate of MOGAT1CompoundRhea RHEA:77563Inferred only
1-hexadecanoylglycerol is a substrate of MOGAT1CompoundRhea RHEA:38123Inferred only
1-octadecanoylglycerol is a substrate of MOGAT1CompoundRhea RHEA:77583Inferred only
1-tetradecanoylglycerol is a substrate of MOGAT1CompoundRhea RHEA:38119Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77287Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77547Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77543Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:39951Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77539Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77271Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77291Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77275Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77279Inferred only
2-(9Z-octadecenoyl)-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77283Inferred only
3-octadecanoyl-sn-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77551Inferred only
a 1-acyl-sn-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77559Inferred only
a 1-acylglycerol is a substrate of MOGAT1CompoundRhea RHEA:39943Inferred only
a 1-acylglycerol is a substrate of MOGAT1CompoundRhea RHEA:77571Inferred only
a 1,2-diacyl-sn-glycerol is a substrate of MOGAT1CompoundHuman-GEM MAR00605Inferred only
a 2-acylglycerol is a substrate of MOGAT1CompoundRhea RHEA:16741Inferred only
a 2-acylglycerol is a substrate of MOGAT1CompoundRhea RHEA:32947Inferred only
a 2-acylglycerol is a substrate of MOGAT1CompoundRhea RHEA:38467Inferred only
a 3-acyl-sn-glycerol is a substrate of MOGAT1CompoundRhea RHEA:77555Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77571Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundHuman-GEM MAR00605Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:39943Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:38467Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77555Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77559Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:32947Inferred only
an acyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:16741Inferred only
butanoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77271Inferred only
dodecanoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77275Inferred only
eicosanoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77543Inferred only
hexadecanoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77283Inferred only
octadecanoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77287Inferred only
octanoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77539Inferred only
tetradecanoyl-CoA is a substrate of MOGAT1CompoundRhea RHEA:77279Inferred only

Reactions

32 reactions

a 1,2-diacyl-sn-glycerol+an acyl-CoACHEBI:1146900+a triacylglycerol
Catalysed by DGAT2 or MOGAT3 or MOGAT1 or MOGAT2 or DGAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.20, 2.3.1.22cytosol
Human-GEM MAR00605CC BY 4.0Reference data
a 2-acylglycerol+an acyl-CoAa 1,2-diacylglycerol+

Other names

8 names

Resolves to: MOGAT1

Also called: Acyl-CoA:monoacylglycerol acyltransferase 1DC2DGAT2L1Diacylglycerol acyltransferase 2-like protein 1Diacylglycerol O-acyltransferase candidate 2hDC2MGAT1Monoacylglycerol O-acyltransferase 1

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Catalysed by MOGAT2 or MOGAT3 or LPGAT1 or TMEM68 or MOGAT1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:16741CC BY 4.0Reference data

a 2-acylglycerol+an acyl-CoAa 1,2-diacyl-sn-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or AWAT2 or MOGAT1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:32947CC BY 4.0Reference data

1-(9Z-octadecenoyl)-glycerol+(9Z)-octadecenoyl-CoA1,2-di-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)

Catalysed by DGAT1 or MOGAT2 or AWAT2 or DGAT2L6 or MOGAT1 or DGAT2

Reaction pageLeft to rightBalanced

Rhea RHEA:37915CC BY 4.0Reference data

1-dodecanoylglycerol+(9Z)-octadecenoyl-CoA1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or MOGAT1

Reaction pageLeft to rightBalanced

Rhea RHEA:38115CC BY 4.0Reference data

1-tetradecanoylglycerol+(9Z)-octadecenoyl-CoA1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or MOGAT1

Reaction pageLeft to rightBalanced

Rhea RHEA:38119CC BY 4.0Reference data

1-hexadecanoylglycerol+(9Z)-octadecenoyl-CoA1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or MOGAT1

Reaction pageLeft to rightBalanced

Rhea RHEA:38123CC BY 4.0Reference data

1-(9Z,12Z-octadecadienoyl)-glycerol+(9Z)-octadecenoyl-CoA1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or MOGAT1

Reaction pageLeft to rightBalanced

Rhea RHEA:38131CC BY 4.0Reference data

1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol+(9Z)-octadecenoyl-CoA1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or MOGAT1

Reaction pageLeft to rightBalanced

Rhea RHEA:38135CC BY 4.0Reference data

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+(9Z)-octadecenoyl-CoA1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or MOGAT1

Reaction pageLeft to rightBalanced

Rhea RHEA:38139CC BY 4.0Reference data

a 2-acylglycerol+an acyl-CoAa 2,3-diacyl-sn-glycerol+coenzyme A(4-)

Catalysed by MOGAT2 or MOGAT1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:38467CC BY 4.0Reference data

a 1-acylglycerol+an acyl-CoAa 1,2-diacylglycerol+coenzyme A(4-)

Catalysed by MOGAT2 or AWAT2 or MOGAT1

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:39943CC BY 4.0Reference data

Show the remaining 20