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Proteins/UNIPROT:Q6E213
Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively. Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that preferentially esterifies 11-cis-retinol, a chromophore precursor of bleached opsin pigments in cone cells. Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates..
Function from UniProtKB (Q6E213), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
83 statements
83 statements · 5 reference databases · Subject: AWAT2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
33 reactions
1,2-diacyl-sn-glycero-3-phosphocholine(1+)+all-trans-retinolMAM00535c+an all-trans-retinyl ester
Catalysed by DGAT2 or RBP2 or RBP1 or LRAT or AWAT2 or DGAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.135, 2.3.1.75cytosol
Human-GEM MAR06635CC BY 4.0Reference data
16 names
Resolves to: AWAT2
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.135, 2.3.1.75cytosol
Human-GEM MAR06639CC BY 4.0Reference data
11-cis-retinol+palmitoyl-CoA11-cis-retinyl hexadecanoate+CHEBI:1146900
Catalysed by DGAT2 or LRAT or AWAT2 or DGAT1 or AWAT1
Reaction pageReversibleBalancedEC 2.3.1.75, 2.3.1.76, 2.3.1.135cytosol
Human-GEM MAR06671CC BY 4.0Reference data
an acyl-CoA+a 1,2-diacyl-sn-glycerola triacyl-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or AWAT2 or MOGAT3 or TMEM68 or DGAT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10868CC BY 4.0Reference data
all-trans-retinol+an acyl-CoAan all-trans-retinyl ester+coenzyme A(4-)
Catalysed by DGAT1 or PNPLA4 or AWAT2 or DGAT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11488CC BY 4.0Reference data
a 2-acylglycerol+an acyl-CoAa 1,2-diacyl-sn-glycerol+coenzyme A(4-)
Catalysed by MOGAT2 or AWAT2 or MOGAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32947CC BY 4.0Reference data
1-(9Z-octadecenoyl)-glycerol+(9Z)-octadecenoyl-CoA1,2-di-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or AWAT2 or DGAT2L6 or MOGAT1 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:37915CC BY 4.0Reference data
2-(9Z-octadecenoyl)-glycerol+hexadecanoyl-CoA1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or AWAT2 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38071CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+hexadecanoyl-CoA1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or AWAT2 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38163CC BY 4.0Reference data
hexadecan-1-ol+hexadecanoyl-CoAhexadecyl hexadecanoate+coenzyme A(4-)
Catalysed by DGAT1 or AWAT1 or AWAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38167CC BY 4.0Reference data
hexadecane-1,2-diol+hexadecanoyl-CoA2-hydroxyhexadecyl hexadecanoate+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:38171CC BY 4.0Reference data
all-trans-retinol+hexadecanoyl-CoAall-trans-retinyl hexadecanoate+coenzyme A(4-)
Catalysed by DGAT1 or PNPLA4 or AWAT2 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38175CC BY 4.0Reference data