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Proteins/UNIPROT:Q8NCG7
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity)..
Function from UniProtKB (Q8NCG7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
36 statements
36 statements · 7 reference databases · Subject: DAGLB · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
20 reactions
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+MAM01807e
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3extracellular space
5 names
Resolves to: DAGLB
Human-GEM MAR00003CC BY 4.0Reference data
a triacylglycerola triacylglycerol
Reaction pageReversibleBalance undeterminablecytosol, endoplasmic reticulum
Human-GEM MAR00664CC BY 4.0Reference data
water+a triacylglycerola 1,2-diacyl-sn-glycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00665CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00667CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00668CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00669CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00670CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00671CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00672CC BY 4.0Reference data
water+an all-trans-retinyl esterproton+all-trans-retinol+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or RBP4 or CES5A or DAGLB or LIPC or CEL or CES3 and 8 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.1, 3.1.1.3cytosol
Human-GEM MAR06636CC BY 4.0Reference data
a triacylglycerol+watera diacylglycerol+a fatty acid+hydron
Catalysed by DDHD2 or LPL or LIPF or ABHD2 or LIPC or PNLIP or CEL or AADAC or PNPLA4 or PNLIPRP2 or LIPE or PNLIPRP3 and 7 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12044CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera 2-acylglycerol+a fatty acid+hydron
Catalysed by DAGLB or ABHD11 or DAGLA
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33275CC BY 4.0Reference data