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Proteins/UNIPROT:Q8NF37
Exhibits acyltransferase activity. Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size..
Function from UniProtKB (Q8NF37), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
132 statements
132 statements · 7 reference databases · Subject: LPCAT1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
37 reactions
1-O-acyl-sn-glycero-3-phosphocholine(1+)+an acyl-CoACHEBI:1146900+1,2-diacyl-sn-glycero-3-phosphocholine(1+)
Catalysed by LPCAT2 or LPCAT3 or LPCAT1 or LPCAT4
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.23cytosol
Human-GEM MAR00632CC BY 4.0Reference data
MAM00511c+an acyl-CoACHEBI:1146900+phosphatidylethanolamine
Catalysed by
15 names
Resolves to: LPCAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.23cytosol
Human-GEM MAR00644CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-cytosol
Human-GEM MAR01088CC BY 4.0Reference data
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
Reaction pageReversibleBalancedEC 2.3.1.-nucleus
Human-GEM MAR01091CC BY 4.0Reference data
1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+an acyl-CoACHEBI:1146900+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine
Catalysed by LPCAT2 or LPCAT3 or LPCAT1 or LPCAT4
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.23cytosol
Human-GEM MAR07602CC BY 4.0Reference data
MAM00549c+CHEBI:15351a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+CHEBI:1146900
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.67cytosol
Human-GEM MAR07613CC BY 4.0Reference data
MAM00549c+an acyl-CoAa 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+CHEBI:1146900
Catalysed by LPCAT2 or LPCAT3 or LPCAT1 or LPCAT4
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.23cytosol
Human-GEM MAR07614CC BY 4.0Reference data
MAM00516c+CHEBI:15351a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+CHEBI:1146900
Catalysed by LPCAT2 or LPCAT1 or LPCAT4
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.67cytosol
Human-GEM MAR08521CC BY 4.0Reference data
a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine+an acyl-CoAa 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:10344CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphocholine+coenzyme A(4-)
Catalysed by PRDX6 or LPCAT4 or LPCAT3 or MBOAT1 or MBOAT2 or LPCAT2 or LPCAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12937CC BY 4.0Reference data
a 1-O-alkyl-sn-glycero-3-phosphocholine+acetyl-CoAa 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+coenzyme A(4-)
Catalysed by LPCAT4 or LPCAT2 or LPCAT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:18461CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphate+an acyl-CoAa 1,2-diacyl-sn-glycero-3-phosphate+coenzyme A(4-)
Catalysed by AGPAT2 or GPAT3 or GPAT2 or LCLAT1 or MBOAT2 or LPCAT2 or LPCAT1 or ABHD5 or AGPAT1 or AGPAT4 or AGPAT3 or PNPLA3 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19709CC BY 4.0Reference data