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Proteins/UNIPROT:Q8IU89
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation..
Function from UniProtKB (Q8IU89), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
51 statements
51 statements · 5 reference databases · Subject: CERS3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
CHEBI:16566+an acyl-CoACHEBI:1146900+an N-acylsphinganine+proton
Catalysed by CERS4 or CERS5 or CERS2 or CERS3 or CERS6 or CERS1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00750CC BY 4.0Reference data
6 names
Resolves to: CERS3
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.24cytosol
Human-GEM MAR00758CC BY 4.0Reference data
sphing-4-enine+a fatty acyl-CoAan N-acylsphing-4-enine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:23768CC BY 4.0Reference data
hexacosanoyl-CoA+sphinganineN-hexacosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:33351CC BY 4.0Reference data
tetracosanoyl-CoA+sphinganineN-tetracosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:33591CC BY 4.0Reference data
docosanoyl-CoA+sphinganineN-docosanoylsphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36535CC BY 4.0Reference data
sphinganine+octadecanoyl-CoAN-(octadecanoyl)-sphinganine+coenzyme A(4-)+hydron
Catalysed by CERS1 or CERS6 or CERS3 or CERS5 or CERS2 or CERS4
Reaction pageLeft to rightBalanced
Rhea RHEA:36547CC BY 4.0Reference data
2-hydroxyoctadecanoyl-CoA+sphinganineN-(2-hydroxyoctadecanoyl)-sphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:36615CC BY 4.0Reference data
2-hydroxydocosanoyl-CoA+sphinganineN-(2-hydroxydocosanoyl)-sphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:36619CC BY 4.0Reference data
2-hydroxytetracosanoyl-CoA+sphinganineN-(2-hydroxytetracosanoyl)-sphinganine+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:36627CC BY 4.0Reference data
octacosanoyl-CoA+sphinganineN-(octacosanoyl)-sphinganine+coenzyme A(4-)+hydron
Catalysed by CERS3
Reaction pageLeft to rightBalanced
Rhea RHEA:36675CC BY 4.0Reference data
a very long-chain fatty acyl-CoA+a sphingoid baseCHEBI:144712+coenzyme A(4-)+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:61480CC BY 4.0Reference data