glutathione

Two steps

• glycodeoxycholate 3-sulfateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• tauroursodeoxycholate 3-sulfateReach from here →
  1. tauroursodeoxycholate(in) + glutathione(in) + ATP + H2O = tauroursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• glycoursodeoxycholate 3-sulfateReach from here →
  1. glycoursodeoxycholate(in) + glutathione(in) + ATP + H2O = glycoursodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• glycochenodeoxycholate 3-sulfateReach from here →
  1. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

• deoxycholateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. Glycodeoxycholate amidohydrolase

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• dimethylarsinous acidReach from here →
  1. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  2. arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by AS3MT

• trimethylarsineReach from here →
  1. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by AS3MT

• CHEBI:28666Reach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. gamma-glutamyltransferase (leukotriene C4)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 6 moreextracellular spaceOne of 5 routes

• a dicarboxylateReach from here →
  1. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by SLC22A13, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• iron(2+)Reach from here →
  1. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  2. Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)

  Catalysed by CLIC1, GSTO1, GSTO2, CYB561D2 and 4 moreinner side of the membrane, outer side of the membrane

• a thiolReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by TSTD1, SUMF1

• formic acidReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. S-Formylglutathione hydrolase

  Catalysed by ESDcytosol

• malonic acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by TSTD1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SQOR, DHODH

• glutarateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by ABCC4, SLC22A24inner side of the membrane, outer side of the membraneOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of arachidonate (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

• nicotinateReach from here →
  1. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  2. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by SLC22A13, SLC22A12inner side of the membrane, outer side of the membrane

• a carboxylic esterReach from here →
  1. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  2. a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)

  Catalysed by CP, PRDX6, CES2, CES1 and 3 more

• methylarsonateReach from here →
  1. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GSR, GSTO1, GSTO2One of 2 routes

• thiosulfateReach from here →
  1. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GSR, TSTD1One of 11 routes

• serotoninReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of serotonin (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• a hydroperoxideReach from here →
  1. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  2. a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O

  Catalysed by CP, PRDX6, PRDX5, PRDX3 and 3 more

• chenodeoxycholateReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. solute carrier organic anion transporter (chenodiol)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• glycolithocholic acidReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• (R)-lactic acidReach from here →
  1. (R)-S-lactoylglutathione = methylglyoxal + glutathione
  2. (R)-S-Lactoylglutathione hydrolase

  Catalysed by GLO1, HAGH, HAGHLcytosolOne of 2 routes

• (S)-lactic acidReach from here →
  1. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  2. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by SLC22A13, SLC22A12inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Cu(+)Reach from here →
  1. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  2. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by CLIC1, GSTO1, GSTO2, CYBRD1inner side of the membrane, outer side of the membrane

• 3,3',5-triiodo-L-thyronineReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SQOR, NQO2

• glycineReach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. leukotriene C4 hydrolysis

  Catalysed by MGST3, GSTM4, LTC4S, MGST2cytosolOne of 6 routes

• choloyl-CoAReach from here →
  1. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by ABCC4, SLC27A5inner side of the membrane, outer side of the membrane

• prostaglandin E1Reach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

• prostaglandin I2Reach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

• prostaglandin H2Reach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

• prostaglandin D2Reach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
  2. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

  Catalysed by GPX1, GPX2, GPX4cytosolOne of 3 routes

• leukotriene A4Reach from here →
  1. leukotriene C4 = leukotriene A4 + glutathione
  2. leukotriene C4 = leukotriene A4 + glutathione

  Catalysed by MGST3, GSTM4, LTC4S, MGST2One of 3 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by TSTD1, MPST

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. glutathione + H2O = L-cysteinylglycine + L-glutamate
  2. gamma-glutamyltransferase (alanine)

  Catalysed by GGT3P, GGT1, GGT5, GGT6 and 3 morecytosol

• taurolithocholate 3-sulfateReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SQOR, PRODH2

• histamineReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of histamine (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by CLIC1, GSTO1, GSTO2, DBHOne of 11 routes

• dopamineReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of dopamine (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by SQOR, PRODH, PRODH2

• estrone 3-sulfateReach from here →
  1. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  2. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes