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Proteins/UNIPROT:P00390
Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol..
Function from UniProtKB (P00390), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
66 statements
66 statements · 6 reference databases · Subject: GSR · Sources: Bgee, Hetionet, Human-GEM, Rhea, UniProt, WikiPathways
5 reactions
glutathione disulfide+proton+NADH(2-)2CHEBI:16856+NAD(+)
Catalysed by GSR
Reaction pageLeft to rightBalancedEC 1.8.1.7cytosol
Human-GEM MAR03868CC BY 4.0Reference data
glutathione disulfide+proton+NADH(2-)2CHEBI:16856+NAD(+)
Catalysed by GSR
4 names
Resolves to: GSR
Human-GEM MAR03869CC BY 4.0Reference data
glutathione disulfide+proton+NADPH(4-)2CHEBI:16856+NADP(3-)
Catalysed by GSR
Reaction pageLeft to rightBalancedEC 1.8.1.7mitochondrial matrix
Human-GEM MAR03870CC BY 4.0Reference data
glutathione disulfide+proton+NADPH(4-)2CHEBI:16856+NADP(3-)
Catalysed by GSR
Reaction pageLeft to rightBalancedEC 1.8.1.7cytosol
Human-GEM MAR04118CC BY 4.0Reference data
2glutathione+NADP(3-)glutathione disulfide+NADPH(4-)+hydron
Catalysed by GSR
Reaction pageDirection not assertedBalanced
Rhea RHEA:11740CC BY 4.0Reference data