S-formylglutathione

Two steps

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by ESD, GPX1, GPX4

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by ESD, GPX4

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. alcohol dehydrogenase (formaldehyde)
  2. formaldehyde to 5,10-methylene-THF conversion

  Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 2 morecytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by ESD, GSTP1

• a quinolReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by ESD, SQOR

• 5(S)-HETEReach from here →
  1. S-Formylglutathione hydrolase
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by ESD, GPX5, GPX1, GPX2 and 6 morecytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• L-ascorbic acidReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by ESD, CLIC1, GSTO1, GSTO2

• chlorine(.)Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of chloride and formate (cytosol to extracellular)

  Catalysed by ESD, SLC26A4cytosol, extracellular spaceOne of 2 routes

• glycocholateReach from here →
  1. S-Formylglutathione hydrolase
  2. solute carrier organic anion transporter (glycocholate)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• cholateReach from here →
  1. S-Formylglutathione hydrolase
  2. solute carrier organic anion transporter (cholate)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• hydrogen sulfideReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by ESD, TSTD1

• acetateReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of acetate and formate (cytosol to extracellular)

  Catalysed by ESD, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

• oxalateReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by ESD, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

• propionic acidReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by ESD, SLC16A4, SLC16A5, SLC16A1cytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of butyrate and formate (cytosol to extracellular)

  Catalysed by ESD, SLC16A4, SLC16A5cytosol, extracellular spaceOne of 2 routes

• an alcoholReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by ESD, CP, PRDX6

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by ESDcytosol, extracellular spaceOne of 2 routes

• serotoninReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ESD, ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. S-Formylglutathione hydrolase
  2. solute carrier organic anion transporter (GSH)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• glycolithocholic acidReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• (S)-lactic acidReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of formate and L-lactate (cytosol to extracellular)

  Catalysed by ESD, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• tert-butanolReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by ESD, CLIC2, GPX1, GPX2 and 2 more

• 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

  Catalysed by ESD, ADI1One of 2 routes

• gamma-Glu-AlaReach from here →
  1. S-Formylglutathione hydrolase
  2. gamma-glutamyltransferase (alanine)

  Catalysed by ESD, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• prostaglandin E1Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. S-Formylglutathione hydrolase
  2. Glutathione: 15-HPETE oxidoreductase

  Catalysed by ESD, GPX5, GPX1, GPX2 and 6 morecytosolOne of 2 routes

• sarcosineReach from here →
  1. alcohol dehydrogenase (formaldehyde)
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 3 morecytosol

• leukotriene A4Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by ESD, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. S-Formylglutathione hydrolase
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by ESD, GLO1, GLOD4cytosolOne of 3 routes

• leukotriene C4Reach from here →
  1. S-Formylglutathione hydrolase
  2. leukotriene C4 synthase (GSH)

  Catalysed by ESD, LTC4ScytosolOne of 5 routes

• glutathione disulfideReach from here →
  1. S-Formylglutathione hydrolase
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by ESD, GPX5, GPX1, GPX2 and 6 morecytosolOne of 35 routes

• taurolithocholate 3-sulfateReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by ESD, CHAC2, CHAC1

• histamineReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• N-formyl-L-kynurenineReach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

  Catalysed by ESD, AFMID

• S-sulfanylglutathioneReach from here →
  1. S-Formylglutathione hydrolase
  2. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by ESD, SQORcytosol, mitochondrial matrixOne of 5 routes

• dopamineReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• prostaglandin E2Reach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• L-cysteinylglycineReach from here →
  1. S-Formylglutathione hydrolase
  2. glutathione gamma-glutamylaminopeptidase

  Catalysed by ESD, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. S-formylglutathione + H2O = formate + glutathione + H(+)
  2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by ESD, SQOR

• (R)-noradrenalineReach from here →
  1. S-Formylglutathione hydrolase
  2. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by ESD, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes