2-oxo-3-sulfanylpropanoate

Three steps

• CHEBI:16523Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular spaceOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by GOT2, GOT1, SLC7A6, ACY1cytosol, extracellular spaceOne of 2 routes

• 2-phenylacetamideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by GOT2, GOT1, SLC7A5, EPXcytosol, extracellular space

• CHEBI:16633Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GOT2, GOT1, SLC7A5, SCLYcytosol, extracellular space

• Met-tRNA(Met)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC7A5, MARS1cytosol, extracellular space

• (R)-glycerateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by MPST, TST, AGXT, GRHPRcytosolOne of 4 routes

• CHEBI:16668Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. L-Cysteine:oxygen oxidoreductase
  3. 3-sulfino-L-alanine carboxy-lyase

  Catalysed by GOT2, GOT1, CDO1, GAD1 and 1 morecytosol

• quinolinic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. Transport of Quinolinic Acid

  Catalysed by MPST, TST, SLC22A6cytosol, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by GOT2, GOT1, SLC7A5, AADATcytosol, extracellular space

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by GOT2, GOT1, SLC7A5, CNDP2cytosol, extracellular spaceOne of 2 routes

• tryptamineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by GOT2, GOT1, SLC7A5, DDCcytosol, extracellular space

• formaldehydeReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

  Catalysed by GOT2, GOT1, MOCOS, KDM1A and 1 morecytosolOne of 4 routes

• pantetheine 4'-phosphateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. (R)-4'-phosphopantothenate:L-cysteine ligase
  3. N-[(R)-4'-Phosphopantothenoyl]-L-cysteine carboxy-lyase

  Catalysed by GOT2, GOT1, PPCS, PPCDCcytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space, peroxisome

• ferrocytochrome cReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. thiosulfate:cyanide sulfurtranserase
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by MPST, TST, SUOXcytosol, mitochondrial matrixOne of 3 routes

• bilirubin IXalphaReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• oxalic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLC6A14, SLC26A6cytosol, extracellular spaceOne of 2 routes

• glycolaldehydeReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by MPST, TST, AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by MPST, TST, NPLcytosolOne of 2 routes

• taurolithocholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• CHEBI:17208Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by GOT2, GOT1cytosol

• homocysteineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. Formation of Homocystine

  Catalysed by GOT2, GOT1cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by GOT2, GOT1, SLC7A6, OATcytosol, extracellular space, mitochondrial matrix

• itaconateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• 17alpha-hydroxyprogesteroneReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, endoplasmic reticulum

• anilineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by GOT2, GOT1, NAGS, NAT2 and 1 morecytosol, mitochondrial matrix

• CHEBI:17312Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by GOT2, GOT1, NAGScytosol, mitochondrial matrixOne of 2 routes

• 3-hydroxy-3-methylglutarateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• all-trans-retinolReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by GOT2, GOT1, MOCOS, RETSATcytosol

• CHEBI:17380Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular spaceOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by GOT2, GOT1, SLC7A5, PRODH2cytosol, extracellular spaceOne of 2 routes

• agmatineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by GOT2, GOT1, SLC7A6cytosol, extracellular space, mitochondrial matrix

• enol-oxaloacetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by MPST, TST, SLC25A10, SDHB and 1 morecytosol, mitochondrial matrix

• AH2Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GOT2, GOT1, SLC7A5, MOCOScytosol, extracellular spaceOne of 27 routes

• 5-aminolevulinic acidReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 4 morecytosol, extracellular space, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by GOT2, GOT1, SLC7A5, IL4I1cytosol, extracellular spaceOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. Steryl-Sulfatase

  Catalysed by MPST, TST, STScytosol, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by GOT2, GOT1, NAGS, HADHA and 2 morecytosol, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of alanine and cysteine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GOT2, GOT1, SLC7A5, AARS1cytosol, extracellular space

• glycine betaineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLC6A14, SLC6A12cytosol, extracellular spaceOne of 3 routes

• 4-methylumbelliferyl acetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space

• trans-urocanateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by GOT2, GOT1, SLC7A6, HALcytosol, extracellular space

• urateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by MPST, TST, LDHB, LDHAL6B and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 7 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GOT2, GOT1, SLC7A5, TPH1 and 1 morecytosol, extracellular space

• methylarsonous acidReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GSTO1, GSTO2

• 4-methyl-2-oxopentanoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GOT1, SLC7A9, SLC3A1 and 1 morecytosol, extracellular space, mitochondrial matrixOne of 4 routes

• all-trans-retinalReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• CHEBI:17927Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by GOT2, GOT1, NAGScytosol, mitochondrial matrixOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by GOT2, GOT1, SLC7A5, TATcytosol, extracellular space, mitochondrial matrixOne of 6 routes

• 4-fumarylacetoacetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by MPST, TST, SLC25A10, FAHcytosol, mitochondrial matrixOne of 2 routes