4-hydroxy-2-oxoglutaric acid

Three steps

• CHEBI:15971Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• CHEBI:16174Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by HOGA1, PKM, PKLR, NME4 and 5 moremitochondrial matrix, cytosolOne of 3 routes

• sulfateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. Glyoxylate:oxygen oxidoreductase
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by HOGA1, HAO1, SLC26A6mitochondrial matrix, peroxisome, extracellular space, cytosolOne of 5 routes

• L-cystineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by HOGA1, AGXT2, SLC7A9, SLC3A1mitochondrial matrix, extracellular space, cytosol

• CHEBI:16284Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by HOGA1, PKM, PKLR, DTYMKmitochondrial matrix, cytosolOne of 3 routes

• 11-cis-retinolReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by HOGA1, CLYBL, DGAT1, LRAT and 3 moremitochondrial matrix, cytosol

• (R)-3-aminoisobutyric acidReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by HOGA1, AGXT2, ABATmitochondrial matrixOne of 3 routes

• L-citrullineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A9 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• L-valineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 13 routes

• L-arginineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 10 routes

• CHEBI:16497Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by HOGA1, PKM, PKLRmitochondrial matrix, cytosol

• CHEBI:16523Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC3A2 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. PROTEIN_BS

  Catalysed by HOGA1, AGXT, AGXT2mitochondrial matrix, cytosolOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by HOGA1, AGXT2, SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by HOGA1, TYW1B, TYW1, MARS1mitochondrial matrix, cytosol

• (R)-glycerateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by HOGA1, AGXT, GRHPRmitochondrial matrix, cytosolOne of 4 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by HOGA1, TYW1B, TYW1, AADATmitochondrial matrix

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by HOGA1, LDHA, LDHB, LDHC and 3 moremitochondrial matrix

• CHEBI:16856Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by HOGA1, AGXT, AGXT2, GSSmitochondrial matrix, cytosol

• CHEBI:16857Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC3A2 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 11 routes

• ferrocytochrome cReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by HOGA1, LDHB, LDHAL6B, CYB5D1mitochondrial matrix, cytosolOne of 2 routes

• glycolaldehydeReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by HOGA1, AGXTmitochondrial matrix, cytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by HOGA1, NPLmitochondrial matrix, cytosolOne of 2 routes

• L-isoleucineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 10 routes

• CHEBI:17203Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 8 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosol, endoplasmic reticulum

• anilineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by HOGA1, CLYBL, NAT2, NAT1mitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by HOGA1, CLYBLmitochondrial matrix, cytosolOne of 2 routes

• sulfiteReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by HOGA1, CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• enol-oxaloacetateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by HOGA1, CLYBL, SDHB, SDHAmitochondrial matrix

• AH2Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by HOGA1, AGXT2, MOCOSmitochondrial matrixOne of 7 routes

• 5-aminolevulinic acidReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by HOGA1, AGXT, AGXT2, ALAS1 and 2 moremitochondrial matrix

• L-cysteineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC3A2 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 26 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by HOGA1, CLYBL, HADHA, ACADVL and 1 moremitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by HOGA1, AGXT2, AARS1mitochondrial matrix, cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 5 moremitochondrial matrix, extracellular space, cytosol

• urateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by HOGA1, LDHB, LDHAL6B, SLC22A12mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:17895Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 12 routes

• all-trans-retinalReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:17927Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by HOGA1, CLYBLmitochondrial matrix, cytosol

• 3-phenylpyruvateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by HOGA1, KYAT1mitochondrial matrix, cytosol

• fumaric acidReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by HOGA1, CLYBL, FHmitochondrial matrix, cytosolOne of 6 routes

• CHEBI:18019Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• thiocyanateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)

  Catalysed by HOGA1, MPST, TSTmitochondrial matrix, cytosol

• 4-fumarylacetoacetateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by HOGA1, FAHmitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by HOGA1, AGXT, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 21 routes

• dTTPReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by HOGA1, PKM, PKLR, ENTPD3 and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by HOGA1, AGXT2, SLC1A4mitochondrial matrix, extracellular space, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by HOGA1, AGXT, AGXT2, GARTmitochondrial matrix, cytosol