chlorine(.)

Three steps

• 3,3',5'-triiodothyronamineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by SLC6A6, MTO1, DIO3extracellular space, cytosol

• L-homocysteine thiolactoneReach from here →
  1. transport of chloride and methionine (cytosol to extracellular)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + ATP = L-homocysteine thiolactone + AMP + diphosphate

  Catalysed by SLC6A14, BHMT2, MARS1extracellular space, cytosol

• L-homocysteinyl-AMPReach from here →
  1. transport of chloride and methionine (cytosol to extracellular)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + ATP + H(+) = L-homocysteinyl-AMP + diphosphate

  Catalysed by SLC6A14, BHMT2, MARS1extracellular space, cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC6A6, BAAT, HADHA, ACADVL and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC6A6, BAAT, HADHA, ACADVL and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC6A6, BAAT, ECHS1, ACAA2 and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC6A6, BAAT, ECHS1, ACAA2 and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by SLC6A9, SLC6A14, GSS, GSTP1extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. taurine to tauroursodeoxycholate conversion
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC6A6, SULT2A1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine to glycoursodeoxycholate conversion
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, SULT2A1extracellular space, cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, BAAT, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. Glycodeoxycholate amidohydrolase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC6A9, SLC6A14extracellular space, cytosol

• a quinolReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by SLC6A9, SLC6A14, GSS, SQORextracellular space, cytosolOne of 5 routes

• octadecanoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. Fas180

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulum

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. fatty acylamide amidohydrolase

  Catalysed by SLC6A14, FAAHextracellular space, cytosol, endoplasmic reticulum

• imidazole-4-acetaldehydeReach from here →
  1. transport of chloride and histidine (cytosol to extracellular)
  2. L-histidine carboxy-lyase (histamine-forming)
  3. amine oxidase copper containing (histamine)

  Catalysed by SLC6A14, HDC, AOC2, AOC1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC6A6, BAAT, ACSM4, ACSM1 and 4 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• selenomethionineReach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by SLC6A14, SDS, SDSL, CTHextracellular space, cytosol

• CHEBI:27760Reach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by SLC6A14, SDS, SDSL, CTHextracellular space, cytosolOne of 2 routes

• elaidic acidReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 5 routes

• 5(S)-HETEReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLC6A9, SLC6A14, GSS, GPX5 and 8 moreextracellular space, cytosolOne of 2 routes

• (2-hydroxyphenyl)acetic acidReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. Phenylalanine Transaminase, Mitochondrial
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by SLC6A14, GOT2, TAT, HPDextracellular space, cytosol, mitochondrial matrix

• 3-mercaptolactic acidReach from here →
  1. transport of chloride and cysteine (cytosol to extracellular)
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by SLC6A14, GOT2, GOT1, LDHB and 3 moreextracellular space, cytosol

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

• CHEBI:28701Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC6A6, BAAT, ACAA1, SCP2 and 1 moreextracellular space, cytosol, peroxisomeOne of 7 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. transport of betaine and chloride (cytosol to extracellular)
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by SLC6A12, SLC22A5, CPT2, CRATextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 17alpha-hydroxypregnenoloneReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetate and formate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A1 and 1 moreextracellular space, cytosol, endoplasmic reticulum

• 3-disulfanyl-L-alanineReach from here →
  1. transport of alanine and chloride (cytosol to extracellular)
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC6A14, SLC7A9, SLC3A1, CTHextracellular space, cytosol

• Mn(2+)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of Ca2+ and K+ (cytosol to extracellular)
  3. Mn(2+)(out) + Ca(2+)(in) = Mn(2+)(in) + Ca(2+)(out)

  Catalysed by SLC12A2, SLC12A1, SLC24A1, SLC24A5 and 4 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• a carboxylateReach from here →
  1. transport of chloride and choline (cytosol to extracellular)
  2. an acylcholine + H2O = a carboxylate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by SLC5A7, BCHEextracellular space, cytosol

• L-ascorbic acidReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by SLC6A9, SLC6A14, GSS, CLIC1 and 2 moreextracellular space, cytosol

• Zn(2+)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of Ca2+ and K+ (cytosol to extracellular)
  3. Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)

  Catalysed by SLC12A2, SLC12A1, SLC24A1, SLC24A5 and 4 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. transport of chloride and leucine (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by SLC6A14, BCAT2, BCKDHA, BCKDHBextracellular space, cytosol, mitochondrial matrix

• Asp-tRNA(Asp)Reach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC12A2, SLC12A1, SLC1A7, SLC1A3 and 4 moreextracellular space, cytosol

• isocyanateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. transport of citrulline and glycine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC6A9, SLC6A14, SLC7A9, SLC3A1 and 2 moreextracellular space, cytosol

• a thiolReach from here →
  1. transport of chloride and cysteine (cytosol to extracellular)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by SLC6A14, CTH, SUMF1extracellular space, cytosol

• hydrogenselenideReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by SLC6A6, MTO1, SCLYextracellular space, cytosol

• cholateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO1A2 and 1 moreextracellular space, cytosolOne of 3 routes

• glycolateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine:oxygen oxidoreductase (deaminating)
  3. glycolate:NADP+ oxidoreductase

  Catalysed by SLC6A9, SLC6A14, DAO, GRHPRextracellular space, cytosol, peroxisomeOne of 3 routes

• 3-acetamidopropanalReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. Transport by Y+Lat-2 into Extracellular Space
  3. N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming)

  Catalysed by SLC6A14, SLC3A2, SLC7A6, PAOX and 1 moreextracellular space, cytosolOne of 2 routes

• anthranilic acidReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. Transport of L-Kynurenine
  3. L-Kynurenine hydrolase

  Catalysed by SLC6A14, SLC7A8, KYNUextracellular space, cytosol

• 3-hydroxypyruvic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

• (indol-3-yl)acetateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SLC26A6, SLC25A35, SLC25A34, SLC22A6 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by SLC6A9, SLC6A14, GSS, CP and 1 moreextracellular space, cytosol

• glutarateReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by SLC6A6, BAAT, SLC22A24, SLC22A8extracellular space, cytosol, peroxisome, inner side of the membrane, outer side of the membraneOne of 10 routes

• pentanoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC26A6, STS, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• D-lysineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC6A6, GATM, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-arginineReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. taurine + L-arginine = taurocyamine + L-ornithine
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC6A6, GATM, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC12A2, SLC12A1, SLC1A7, SLC1A3 and 4 moreextracellular space, cytosolOne of 2 routes

• tetra-mu3-sulfido-tetrairon(2+)Reach from here →
  1. transport of chloride and cysteine (cytosol to extracellular)
  2. De novo synthesis of 2Fe2S
  3. Synthesis of 4Fe4S from 2Fe2S

  Catalysed by SLC6A14, NDUFAB1, FDXR, FXN and 10 moreextracellular space, cytosol, mitochondrial matrix