a dicarboxylate

Three steps

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SLC25A35, SLC25A34, SLC25A10, ADSL and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• an N-acylglycineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYAT, GLYATL3 and 1 moreinner side of the membrane, outer side of the membrane

• S-formylglutathioneReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLC22A6, SLCO2A1, ADH1C, ADH1A and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• guanidinoacetateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by SLC22A6, SLC22A8, GLYAT, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• L-methionineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A8, GLYAT, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 9 routes

• adenosine 5'-phosphoramidateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. ATP:sulfate adenylyltransferase
  3. adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + sulfate + 2 H(+)

  Catalysed by SLC25A35, SLC25A34, PAPSS1, PAPSS2 and 1 moreinner side of the membrane, outer side of the membrane, cytosol

• L-tryptophanReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A8, GLYAT, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 11 routes

• L-dopaquinoneReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  3. 2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O

  Catalysed by SLC22A6, SLC22A8, TH, TYRinner side of the membrane, outer side of the membraneOne of 2 routes

• beta-alanineReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC25A35, SLC25A34, SLC26A6, SLC6A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• L-alanineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. transport of alanine and glycine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A8, GLYAT, SLC3A2 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 9 routes

• leukotriene C4Reach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. leukotriene C4 hydrolysis

  Catalysed by SLC22A6, SLC22A8, GLYATinner side of the membrane, outer side of the membrane, cytosolOne of 8 routes

• L-asparagineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. transport of asparagine and glycine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A8, GLYATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by SLC25A35, SLC25A34, SLC25A14, SLC25A30 and 1 moreinner side of the membrane, outer side of the membrane

• L-phenylalanineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by SLC22A6, SLC22A8, GLYAT, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 15 routes

• glutathione disulfideReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLC22A6, SLCO2A1, GPX5, GPX1 and 7 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 36 routes

• taurolithocholate 3-sulfateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC22A6, SLC22A8, GLYAT, AGXT2inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by SLC22A6, SLC22A13, CHAC2, CHAC1inner side of the membrane, outer side of the membrane

• histamineReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by SLC25A35, SLC25A34, SLC25A10, ADSLinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• D-glucosamineReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC25A35, SLC25A34, SGSHinner side of the membrane, outer side of the membrane

• S-sulfanylglutathioneReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLC22A6, SLCO2A1, SQORinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYAT, GLYATL2inner side of the membrane, outer side of the membraneOne of 2 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. ascorbate to monodehydroascorbate conversion
  3. 8-peroxy-(5Z,9E,11Z,14Z)... to 5,9-cyclo-6,8-cycloperoxy-12... conversion

  Catalysed by SLC22A6inner side of the membrane, outer side of the membrane, cytosolOne of 8 routes

• 4-aminobutanoateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC25A35, SLC25A34, SLC26A6, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• dopamineReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  3. L-dopa + H(+) = dopamine + CO2

  Catalysed by SLC22A6, SLC22A8, TH, DDCinner side of the membrane, outer side of the membraneOne of 5 routes

• (2S)-2-phospholactateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. prostaglandin F2alpha(out) + 2 (S)-lactate(in) = prostaglandin F2alpha(in) + 2 (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by SLC22A6, SLCO2A1, PGPinner side of the membrane, outer side of the membraneOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 3-sulfino-L-alanineReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by SLC25A35, SLC25A34, SLC25A14, SLC25A30 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• L-cysteinylglycineReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLC22A6, SLCO2A1, GGTLC3, GGT1 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by SLC22A6, SLC22A13, SQORinner side of the membrane, outer side of the membraneOne of 2 routes

• (R)-noradrenalineReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• (2S)-2-aminobutanoateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by SLC22A6, SLC22A8, GLYAT, AGXT2inner side of the membrane, outer side of the membrane

• NAADP(+)Reach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)
  3. nicotinate + NADP(+) = NAADP(+) + nicotinamide

  Catalysed by SLC22A6, SLC22A12, SLC22A13, CD38inner side of the membrane, outer side of the membraneOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by SLC22A6, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SLC22A6, SLC22A13, GPX1, GPX4inner side of the membrane, outer side of the membrane

• ursodeoxycholateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• prostaglandin G2Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLC22A8, SLC22A6, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC22A6, SLC22A8, GLYATinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC22A6, SLC22A13, GPX1, GPX2 and 1 moreinner side of the membrane, outer side of the membrane

• 1-O-(1,2-saturated-alkyl)-sn-glycerolReach from here →
  1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)
  2. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O
  3. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by SLC22A6, SLC22A8, AGMOinner side of the membrane, outer side of the membraneOne of 2 routes

• 11beta-prostaglandin F2Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. aldo-keto reductase (prostaglandin D2)
  3. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

  Catalysed by SLC22A6, AKR1C3, AKR1C2inner side of the membrane, outer side of the membrane, cytosol

• N-tetradecanoylglycineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYAT, GLYATL2inner side of the membrane, outer side of the membrane

• N-eicosanoylglycinateReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYAT, BAATinner side of the membrane, outer side of the membrane

• N-docosanoylglycineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYAT, BAATinner side of the membrane, outer side of the membrane

• N-hexacosanoylglycineReach from here →
  1. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)
  2. benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SLC22A6, SLC22A8, GLYAT, BAATinner side of the membrane, outer side of the membrane

• 16alpha-hydroxydehydroepiandrosterone 3-sulfateReach from here →
  1. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC25A35, SLC25A34, STS, CYP3A7inner side of the membrane, outer side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC22A6, SLC22A13, PTGES, MGST3 and 4 moreinner side of the membrane, outer side of the membrane