PGP

Phosphatase with activity against multiple substrates. Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products. Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions. This controls triosephosphate isomerase activity, glycerolipid partitioning and cell proliferation in the embryo and is required for embryonic development (By similarity). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase. Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway. Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction. This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur. Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism. Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear. In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (By similarity)..

Function from UniProtKB (A6NDG6), read 2026-09-23. CC BY 4.0.