Compound
NAADP(+)
An organophosphate oxoanion obtained by deprotonation of the phosphate, diphosphate and carboxy groups of nicotinic acid-adenine dinucleotide phosphate.
Definition from ChEBI (CHEBI:75967), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound, anion
- Formula
- C21H23N6O18P3
- Mass
- 740.361 g/mol
- Charge
- -4
- InChIKey
- QOTXBMGJKFVZRD-HISDBWNOSA-J
- SMILES
- Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)([O-])OP(=O)([O-])OC[C@H]2O[C@@H]([n+]3cccc(C(=O)[O-])c3)[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1OP(=O)([O-])[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- G6PDProteinUNIPROT:P11413substrate ofInferred only34 paths34 endpoints
- CD38ProteinUNIPROT:P28907substrate ofInferred only14 paths14 endpoints
- DUOX2ProteinUNIPROT:Q9NRD8substrate ofInferred only9 paths9 endpoints
- NOX5ProteinUNIPROT:Q96PH1substrate ofInferred only5 paths5 endpoints
- DUOX1ProteinUNIPROT:Q9NRD9substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: NAADP(+) · Sources: Rhea
- NAADP(+) is converted to NAADPHCompoundRhea RHEA:86235Inferred only
- NAADPH is converted to NAADP(+)CompoundRhea RHEA:86235Inferred only
- NAADP(+) is a substrate of CD38ProteinRhea RHEA:38607Inferred only
- NAADP(+) is a substrate of DUOX1ProteinRhea RHEA:86235Inferred only
- NAADP(+) is a substrate of DUOX2ProteinRhea RHEA:86235Inferred only
- NAADP(+) is a substrate of G6PDProteinRhea RHEA:86243Inferred only
- NAADP(+) is a substrate of NOX5ProteinRhea RHEA:86239Inferred only
Reactions
5 reactions
nicotinate+NADP(3-)NAADP(+)+nicotinamide
Catalysed by CD38
Reaction pageLeft to rightBalanced
Rhea RHEA:38599CC BY 4.0Reference data
2'-phospho-cyclic ADP-ribose+nicotinateNAADP(+)
Catalysed by CD38
Reaction pageReversibleBalanced
Rhea RHEA:38607CC BY 4.0Reference data
NAADPH+dioxygen+hydronNAADP(+)+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:86235CC BY 4.0Reference data
NAADPH+2dioxygenNAADP(+)+2superoxide+hydron
Catalysed by NOX5
Reaction pageDirection not assertedBalanced
Rhea RHEA:86239CC BY 4.0Reference data
NAADP(+)+D-glucose 6-phosphateNAADPH+6-phospho-D-glucono-1,5-lactone+hydron
Catalysed by G6PD
Reaction pageDirection not assertedBalanced
Rhea RHEA:86243CC BY 4.0Reference data
Other names
3 names
Resolves to: NAADP(+)
- Also called
- NAADP(4+)nicotinate-adenine dinucleotide phosphate(4-)nicotinate-adenine dinucleotide phosphate(4−)