propanoate

Three steps

• urateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by SLC22A9, SLC22A24, SLC22A8, SLC22A11inner side of the membrane, outer side of the membraneOne of 2 routes

• fumaric acidReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by SLC22A9, STS, SLC25A10inner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrixOne of 2 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLC22A9, SLC22A24, SLC22A8, SLC22A11inner side of the membrane, outer side of the membraneOne of 2 routes

• androst-5-en-3beta,17beta-diolReach from here →
  1. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. 3beta-hydroxyandrost-5-en-17-one + NADPH + H(+) = androst-5-en-3beta,17beta-diol + NADP(+)

  Catalysed by SLC22A9, STS, AKR1B15, HSD17B3inner side of the membrane, outer side of the membrane, cytosol

• folic acidReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. Folate Transport by Oats

  Catalysed by SLC22A9, STS, SLC22A8, SLC22A7inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 2 routes

• 3beta,16alpha-dihydroxy-androst-5-en-17-oneReach from here →
  1. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. 3beta-hydroxyandrost-5-en-17-one + reduced [NADPH--hemoprotein reductase] + O2 = 3beta,16alpha-dihydroxy-androst-5-en-17-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC22A9, STS, CYP17A1, CYP3A7inner side of the membrane, outer side of the membrane, cytosol

• CHEBI:28666Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of LTD4 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLC22A9, STS, CYP17A1inner side of the membrane, outer side of the membrane, cytosol, endoplasmic reticulum

• a dicarboxylateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A35, SLC25A34inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• chlorine(.)Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SLC22A9, STS, SLC26A6inner side of the membrane, outer side of the membrane, cytosol, extracellular space

• glycocholateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• cholateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• oxalateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC26A2 and 3 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• maleateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• malonic acidReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SLC22A9, STS, SLC25A10inner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrixOne of 2 routes

• adipic acidReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by SLC22A9, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membrane

• (2R,3R)-tartrateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (S,S)-tartrateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (3R)-citramalateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (3S)-citramalateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• thiosulfateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLC22A9, STS, SLC25A14, SLC25A30 and 2 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• serotoninReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• taurocholateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• glyoxylateReach from here →
  1. propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by ACSM3, ACSS3, ACSS2, ACSS1 and 1 more

• glycolithocholic acidReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (R)-methylmalonyl-CoAReach from here →
  1. propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate
  2. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  3. Methylmalonyl-CoA epimerase

  Catalysed by ACSM3, ACSS3, ACSS2, ACSS1 and 3 moremitochondrial matrixOne of 2 routes

• butanoyl-CoAReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)
  3. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate

  Catalysed by SLC22A9, ACSM1, ACSM2A, ACSM3 and 2 moreinner side of the membrane, outer side of the membrane

• glutaryl-CoAReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by SLC22A9, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin E1Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• prostaglandin I2Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• prostaglandin D2Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N-sulfo-D-glucosamineReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SLC22A9, STS, SGSHinner side of the membrane, outer side of the membrane, cytosol

• leukotriene C4Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. ATP:sulfate adenylyltransferase

  Catalysed by SLC22A9, STS, PAPSS1, PAPSS2inner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• taurolithocholate 3-sulfateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• histamineReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• kynurenateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by SLC22A9, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• dopamineReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLCO1B3inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SLC22A9, STS, SLC4A1inner side of the membrane, outer side of the membrane, cytosol, extracellular spaceOne of 2 routes