androst-5-en-3beta,17beta-diol

1. androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + NADH + H(+)

Catalysed by HSD3B1

1. 3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)

Catalysed by HSD3B1, HSD3B2cytosolOne of 3 routes

1. androst-5-en-3beta,17beta-diol + reduced [NADPH--hemoprotein reductase] + O2 = androst-5-en-3beta,7alpha,17beta-triol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP7B1

1. 3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)
2. glucuronosyltransferase (5-alpha-dihydrotestosterone)

Catalysed by HSD3B1, HSD3B2, UGT2B4, UGT1A1 and 3 morecytosol, endoplasmic reticulumOne of 2 routes

1. 3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)
2. steroid sulfatase (5-alpha-dihydrotestosterone)

Catalysed by HSD3B1, HSD3B2

1. androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + NADH + H(+)
2. 17beta-hydroxy-androst-5-en-3-one = testosterone
3. 17beta-hydroxysteroid UDP-glucuronosyltransferase

Catalysed by HSD3B1, UGT2B17, UGT2B7, UGT1A1 and 3 moreendoplasmic reticulumOne of 2 routes

1. 3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)
2. glucuronosyltransferase (5-alpha-dihydrotestosterone)
3. 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + UDP + H(+)