sn-glycerol 3-phosphocholine

Three steps

• (S)-dihydroorotateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by GDPD5, GPCPD1, GPD2, DHODH

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by ENPP6, PLA2G4A, ABHD16A, ABHD12 and 2 more

• beta-D-fructose 1,6-bisphosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

  Catalysed by GDPD5, GPCPD1, GPD1, GPD1L and 3 more

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerolReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)
  3. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate

  Catalysed by GPCPD1, GPAT3, GPAT2, GPAT4 and 2 morecytosol

• fatty acidReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-acylglycerol acylhydrolase

  Catalysed by ENPP6, LIPE, ABHD12, MGLL and 1 morecytosolOne of 7 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. sn-Glycero-3-phosphocholine cholinephosphohydrolase
  2. CTP:choline-phosphate cytidylyltransferase
  3. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)

  Catalysed by ENPP6, PCYT1A, PCYT1B, CHPT1 and 1 morecytosolOne of 2 routes

• a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. sn-Glycero-3-phosphocholine cholinephosphohydrolase
  2. CTP:choline-phosphate cytidylyltransferase
  3. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase

  Catalysed by ENPP6, PCYT1A, PCYT1B, CHPT1 and 1 morecytosol

• 25-hydroxycholesterolReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by GPCPD1, CHDH, CH25Hcytosol

• 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  3. 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)

  Catalysed by ENPP6, PCYT1A, PCYT1B, CEPT1

• taurineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by GPCPD1, CHAT, BAATcytosolOne of 4 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by GPCPD1, CHDH, RETSATcytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO2cytosol

• 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  3. 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)

  Catalysed by ENPP6, PCYT1A, PCYT1B, CEPT1

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by GDPD5, GPCPD1, GPD2, NQO2

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by GPCPD1, CHDH, DIO1, DIO3cytosol

• glycineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by GPCPD1, CHAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 13 routes

• (R)-methylmalonyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by GPCPD1, CHAT, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by GPCPD1, CHATcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by GPCPD1, CHAT, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by GPCPD1, CHATcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by GPCPD1, CHAT, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by GPCPD1, CHAT, ACSM4, ACSM1 and 4 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by GPCPD1, CHAT, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by GPCPD1, CHAT, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by GPCPD1, CHAT, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by GPCPD1, CHATcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by GPCPD1, CHAT, SLC27A2, ACSL4 and 5 morecytosolOne of 15 routes

• prostaglandin H2Reach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

  Catalysed by GPCPD1, CHDH, PTGS1, PTGS2cytosolOne of 2 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by GPCPD1, CHDH, TBXAS1, PTGS2 and 1 morecytosol

• a 1-acylglycerone 3-phosphateReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by GDPD5, GPCPD1, GPD1, GPD1L and 1 more

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  2. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
  3. CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)

  Catalysed by ENPP6, PCYT1A, PCYT1B, CHPT1 and 1 more

• guanidinoacetateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by GPCPD1, SLC5A7cytosol, extracellular space

• sphing-4-enineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GPCPD1, CHAT, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by GPCPD1, CHAT, SAT1, SAT2cytosolOne of 3 routes

• L-methionineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by GPCPD1, CHAT, NAGScytosol, mitochondrial matrixOne of 7 routes

• L-tryptophanReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• beta-alanineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by GPCPD1, SLC5A7, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by GPCPD1, CHATcytosol, mitochondrial matrixOne of 5 routes

• L-asparagineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by GPCPD1, CHAT, NAGScytosol, mitochondrial matrixOne of 3 routes

• L-phenylalanineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by GPCPD1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L,L-cystathionineReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by GPCPD1, CHAT, NAGScytosol, mitochondrial matrix

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by GPCPD1, GPD2, GNPATcytosol, mitochondrial matrix, peroxisomeOne of 3 routes

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
  3. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)

  Catalysed by GDPD5, GPCPD1, PGS1

• an acyl-CoAReach from here →
  1. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GPCPD1, CHAT, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 3 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by GDPD5, GPCPD1, GPD2, PRODH2