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1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

11 compounds within 3 steps: 1 in 1, 2 in 2, 8 in 3

Does it reach a compound?

One step

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
Catalysed by AGK

Two steps

1-acyl-sn-glycerol 3-phosphateReach from here →
1. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
2. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
Catalysed by AGKcytosolOne of 8 routes
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphateReach from here →
1. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
Catalysed by AGK, GPAT3, ABHD5, AGPAT5

Three steps

CHEBI:1146900Reach from here →
Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrixOne of 8 routes
1-acylglycerone 3-phosphateReach from here →

Catalysed by AGK, AKR1A1cytosol

phosphatidic acidReach from here →

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

Catalysed by AGK, AGPAT2, LCLAT1, MBOAT1 and 6 morecytosol, mitochondrial matrixOne of 8 routes

1-hexadecanoyl-sn-glycero-3-phosphateReach from here →

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
1-acylglycerol-3-phosphate pool formation and breakdown

Catalysed by AGKcytosol

1-dodecanoyl-sn-glycerol 3-phosphateReach from here →

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
1-acylglycerol-3-phosphate pool formation and breakdown

Catalysed by AGKcytosol

1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
1-acylglycerol-3-phosphate pool formation and breakdown

Catalysed by AGKcytosol

1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
1-acylglycerol-3-phosphate pool formation and breakdown

Catalysed by AGKcytosol

1-octadecanoyl-sn-glycero-3-phosphateReach from here →

1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)
1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation
1-acylglycerol-3-phosphate pool formation and breakdown

Catalysed by AGKcytosol