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Proteins/UNIPROT:Q8N2K0
Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Prefers as substrates lysophosphatidylserines having long and very long chain acyl chains. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding..
Function from UniProtKB (Q8N2K0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
97 statements
97 statements · 6 reference databases · Subject: ABHD12 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
33 reactions
MAM01570eMAM01569e+77243a triacylglycerol
Catalysed by MGLL or ABHD12 or SDC1 or ABHD6 or LPL or GPIHBP1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34, 3.1.1.23extracellular space
Human-GEM MAR00001CC BY 4.0Reference data
a monoacylglycerol+waterMAM01807c+MAM01983c
Catalysed by MGLL
6 names
Resolves to: ABHD12
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00005CC BY 4.0Reference data
MAM03147e10385a triacylglycerol+MAM03146e
Catalysed by MGLL or ABHD12 or SDC1 or ABHD6 or LPL or GPIHBP1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.34, 3.1.1.23extracellular space
Human-GEM MAR00006CC BY 4.0Reference data
a monoacylglycerol+waterfatty acid+MAM01983c
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00010CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00679CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00680CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00681CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00682CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00683CC BY 4.0Reference data
a monoacylglycerol+waterMAM01983c+proton+fatty acid
Catalysed by MGLL or ABHD12 or ABHD6
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.23cytosol
Human-GEM MAR00684CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+waterglycerol+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by FAAH or CES2 or ABHD16A or EPHX1 or ABHD2 or CES1 or LIPE or PNPLA6 or ABHD12 or MGLL or ABHD6
Reaction pageLeft to rightBalanced
Rhea RHEA:26132CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phospho-L-serine+watersn-glycero-3-phospho-L-serine+a fatty acid+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32979CC BY 4.0Reference data