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Proteins/UNIPROT:Q8WUD6
Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes..
Function from UniProtKB (Q8WUD6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
103 statements
103 statements · 8 reference databases · Subject: CHPT1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
9 reactions
a 1,2-diacyl-sn-glycerol+CHEBI:16436MAM01395c+cytidine 5'-monophosphate+proton
Reaction pageLeft to rightBalance undeterminableEC 2.7.8.2cytosol
Human-GEM MAR00468CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+CHEBI:16436cytidine 5'-monophosphate+proton+1,2-diacyl-sn-glycero-3-phosphocholine(1+)
4 names
Resolves to: CHPT1
Reaction pageLeft to rightBalance undeterminableEC 2.7.8.2cytosol
Human-GEM MAR00625CC BY 4.0Reference data
1-O-alkyl-2-acyl-sn-glycerol+CHEBI:16436a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+cytidine 5'-monophosphate+proton
Reaction pageLeft to rightBalance undeterminableEC 2.7.8.2cytosol
Human-GEM MAR07600CC BY 4.0Reference data
a 1-O-alkyl-2-acetyl-sn-glycerol+CHEBI:16436a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+cytidine 5'-monophosphate+proton
Reaction pageReversibleBalance undeterminableEC 2.7.8.2cytosol
Human-GEM MAR07610CC BY 4.0Reference data
CDP-choline+a 1,2-diacyl-sn-glycerola 1,2-diacyl-sn-glycero-3-phosphocholine+CMP+hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32939CC BY 4.0Reference data
1,2-dioctanoyl-sn-glycerol+CDP-choline1,2-dioctanoyl-sn-glycero-3-phosphocholine+CMP+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:54232CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol+CDP-choline1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+CMP+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:54244CC BY 4.0Reference data
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol+CDP-choline1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine+CMP+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:54332CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+CDP-choline1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+CMP+hydron
Catalysed by CHPT1
Reaction pageLeft to rightBalanced
Rhea RHEA:54344CC BY 4.0Reference data