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Proteins/UNIPROT:Q86UL3

GPAT4

Protein·UNIPROT:Q86UL3Glycerol-3-phosphate acyltransferase 4

Open in the graph

Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Active against both saturated and unsaturated long-chain fatty acyl-CoAs. Protects cells against lipotoxicity..

Function from UniProtKB (Q86UL3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

177 statements

177 statements · 6 reference databases · Subject: GPAT4 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

GPAT4 covaries with BLOC1S3ProteinHetionet hetionet:covaries:137964-388552Inferred only
GPAT4 covaries with EXOSC6ProteinHetionet hetionet:covaries:118460-137964Inferred only
GPAT4 is expressed in adrenal cortexAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in adrenal glandAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in apex of heartAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in body of pancreasAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in body of stomachAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in body of uterusAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in cerebellar cortexAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in cerebellar hemisphereAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in cerebellumAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in endocervixAnatomyBgee ENSG00000158669Inferred only

Show the remaining 165

GPAT4 is expressed in gallbladderAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in gastrocnemiusAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in granulocyteCell typeBgee ENSG00000158669Inferred only
GPAT4 is expressed in hindlimb stylopod muscleAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in islet of LangerhansAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in left adrenal glandAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in left adrenal gland cortexAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in left fallopian tubeAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in left lobe of thyroid glandAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in left ovaryAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in left testisAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in leukocyteCell typeBgee ENSG00000158669Inferred only
GPAT4 is expressed in minor salivary glandAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in monocyteCell typeBgee ENSG00000158669Inferred only
GPAT4 is expressed in mucosa of stomachAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in pancreasAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in peritoneumAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in rectumAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right adrenal glandAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right adrenal gland cortexAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right hemisphere of cerebellumAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right lobe of liverAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right lobe of thyroid glandAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right lungAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right ovaryAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in right testisAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in saliva-secreting glandAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in skin of legAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in small intestine Peyer's patchAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in smooth muscle tissueAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in spleenAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in stromal cell of endometriumCell typeBgee ENSG00000158669Inferred only
GPAT4 is expressed in tendon of biceps brachiiAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in tibial nerveAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in transverse colonAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in upper lobe of left lungAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in vaginaAnatomyBgee ENSG00000158669Inferred only
GPAT4 is expressed in vermiform appendixAnatomyBgee ENSG00000158669Inferred only
GFI1B interacts with GPAT4ProteinHetionet hetionet:interacts:137964-8328Inferred only
HSD17B7 interacts with GPAT4ProteinHetionet hetionet:interacts:137964-51478Inferred only
UBC interacts with GPAT4ProteinHetionet hetionet:interacts:137964-7316Inferred only
GPAT4 participates in Glycerolipids and glycerophospholipidsPathwayWikiPathways WP4722Inferred only
GPAT4 participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
GPAT4 participates in Glycerophospholipid biosynthetic pathwayPathwayWikiPathways WP2533Inferred only
GPAT4 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GPAT4 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
GPAT4 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
GPAT4 participates in Synthesis of PAPathwayReactome R-HSA-1483166Inferred only
(11Z,14Z,17Z)-eicosatrienoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00530Inferred only
(11Z,14Z)-eicosadienoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00542Inferred only
(11Z)-docosenoyl-CoA(4-) is a substrate of GPAT4CompoundHuman-GEM MAR00516Inferred only
(11Z)-eicosenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00509Inferred only
(13Z)-docosenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00515Inferred only
(13Z)-eicosenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00508Inferred only
(15Z)-tetracosenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00519Inferred only
(17Z)-hexacosenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00521Inferred only
(2E)-hexadecenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR02308Inferred only
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00529Inferred only
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00541Inferred only
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00525Inferred only
(5Z)-tetradecenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00491Inferred only
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00528Inferred only
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00523Inferred only
(6Z,9Z,12Z)-octadecatrienoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00535Inferred only
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00526Inferred only
(7Z)-hexadecenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00495Inferred only
(7Z)-octadecenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00504Inferred only
(7Z)-tetradecenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00490Inferred only
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00524Inferred only
(8Z,11Z,14Z)-eicosatrienoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00536Inferred only
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00527Inferred only
(9Z,12Z,15Z)-octadecatrienoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00522Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAT4CompoundRhea RHEA:37203Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00534Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00505Inferred only
(9Z)-heptadecenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00498Inferred only
(9Z)-hexadecenoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00494Inferred only
(9Z)-octadecenoyl-CoA is a substrate of GPAT4CompoundRhea RHEA:37199Inferred only
an acyl-CoA is a substrate of GPAT4CompoundRhea RHEA:15325Inferred only
an acyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00579Inferred only
arachidonoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00537Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00526Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00527Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00486Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00487Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00488Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00489Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00490Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00491Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00492Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00493Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00494Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00495Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00496Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00497Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00498Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00499Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00500Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00501Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00502Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00503Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00504Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00505Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00506Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00507Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00508Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00509Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00510Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00511Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00512Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00513Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00514Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00515Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00516Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00517Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00518Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00519Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00520Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00521Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00522Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00523Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00524Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00525Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00528Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00529Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00530Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00531Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00532Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00533Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00534Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00535Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00536Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00537Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00538Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00539Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00540Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00541Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00542Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00543Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00544Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR00579Inferred only
CHEBI:15978 is a substrate of GPAT4CompoundHuman-GEM MAR02308Inferred only
CHEBI:63544 is a substrate of GPAT4CompoundHuman-GEM MAR00538Inferred only
docosanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00514Inferred only
dodecanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00486Inferred only
dodecanoyl-CoA is a substrate of GPAT4CompoundRhea RHEA:35727Inferred only
eicosanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00507Inferred only
elaidic acid is a substrate of GPAT4CompoundHuman-GEM MAR00503Inferred only
heptadecanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00496Inferred only
hexacosanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00520Inferred only
hexadecanoyl-CoA is a substrate of GPAT4CompoundRhea RHEA:35723Inferred only
nonadecanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00506Inferred only
octadecanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00499Inferred only
octadecanoyl-CoA is a substrate of GPAT4CompoundRhea RHEA:37195Inferred only
oleoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00502Inferred only
palmitoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00493Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT4CompoundRhea RHEA:37195Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT4CompoundRhea RHEA:35723Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT4CompoundRhea RHEA:15325Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT4CompoundRhea RHEA:35727Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT4CompoundRhea RHEA:37199Inferred only
sn-glycerol 3-phosphate is a substrate of GPAT4CompoundRhea RHEA:37203Inferred only
tetracosanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00518Inferred only
tetradecanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00488Inferred only
tricosanoyl-CoA is a substrate of GPAT4CompoundHuman-GEM MAR00517Inferred only

Reactions

67 reactions

dodecanoyl-CoA+CHEBI:159781-dodecanoyl-sn-glycerol 3-phosphate+CHEBI:1146900
Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2
Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol
Human-GEM MAR00486CC BY 4.0Reference data
CHEBI:15978+MAM03050cMAM00502c+CHEBI:1146900
Catalysed by GPAM

Other names

9 names

Resolves to: GPAT4

Also called: 1-acylglycerol-3-phosphate O-acyltransferase 61-AGP acyltransferase 61-AGPAT 6Acyl-CoA:glycerol-3-phosphate acyltransferase 4AGPAT6LPAAT-zetaLysophosphatidic acid acyltransferase zetaTestis spermatogenesis apoptosis-related protein 7TSARG7

← Every protein Find it in the graph →

or

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00487CC BY 4.0Reference data

tetradecanoyl-CoA+CHEBI:159781-tetradecanoyl-sn-glycerol 3-phosphate+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00488CC BY 4.0Reference data

MAM00129c+CHEBI:15978MAM00471c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00489CC BY 4.0Reference data

(7Z)-tetradecenoyl-CoA+CHEBI:15978MAM00463c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00490CC BY 4.0Reference data

(5Z)-tetradecenoyl-CoA+CHEBI:15978MAM00454c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00491CC BY 4.0Reference data

MAM02689c+CHEBI:15978MAM00498c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00492CC BY 4.0Reference data

palmitoyl-CoA+CHEBI:159781-hexadecanoyl-sn-glycero-3-phosphate+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00493CC BY 4.0Reference data

(9Z)-hexadecenoyl-CoA+CHEBI:15978MAM00497c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00494CC BY 4.0Reference data

(7Z)-hexadecenoyl-CoA+CHEBI:15978MAM00461c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00495CC BY 4.0Reference data

heptadecanoyl-CoA+CHEBI:15978MAM00481c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00496CC BY 4.0Reference data

MAM00004c+CHEBI:15978MAM00438c+CHEBI:1146900

Catalysed by GPAM or GPAT3 or GPAT4 or GPAT2

Reaction pageLeft to rightBalancedEC 2.3.1.15cytosol

Human-GEM MAR00497CC BY 4.0Reference data

Show the remaining 55