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Proteins/UNIPROT:P47712
Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response. Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophospholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis..
Function from UniProtKB (P47712), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
318 statements
318 statements · 7 reference databases · Subject: PLA2G4A · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
29 reactions
5 names
Resolves to: PLA2G4A
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum
Human-GEM MAR00463CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00630CC BY 4.0Reference data
1-O-acyl-sn-glycero-3-phosphocholine(1+)+waterproton+sn-glycerol 3-phosphocholine+fatty acid
Catalysed by LYPLA2 or PNPLA6 or PLA2G15 or PLA2G4A or LYPLA1 or PNPLA7 or PNPLA8 or PLB1 or ASPG or CLCF1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.5cytosol
Human-GEM MAR00633CC BY 4.0Reference data
water+phosphatidylethanolamineMAM00511c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR00643CC BY 4.0Reference data
MAM00511c+waterproton+MAM02913c+fatty acid
Catalysed by LYPLA2 or PNPLA6 or PLA2G15 or PLA2G4A or LYPLA1 or PNPLA7 or PNPLA8 or PLB1 or ASPG or CLCF1
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.5cytosol
Human-GEM MAR00645CC BY 4.0Reference data
water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome
Human-GEM MAR05254CC BY 4.0Reference data
water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07603CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol
Human-GEM MAR07615CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+watersn-glycerol 3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G6 or PLA2G4B or LIPC or PLA2G4A or PLB1 or PNPLA7 or ASPG or PNPLA6 or PLA2G15 or PNPLA8 or PLA2G4C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15177CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15801CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G6 or PLA2G4A or PLA2G4F or PLB1 or PAFAH2 or PLA2G4C
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36231CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron
Catalysed by PLA2G6 or PLA2G1B or LCAT or PLA2G4B or PLA2G5 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F or PLA2G4D or PNPLA8 or PLA2G3 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:40427CC BY 4.0Reference data