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Proteins/UNIPROT:Q6UWR7
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity)..
Function from UniProtKB (Q6UWR7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 5 reference databases · Subject: ENPP6 · Sources: Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
12 reactions
water+sn-glycerol 3-phosphocholineMAM01983c+proton+CHEBI:18132
Catalysed by ENPP6
Reaction pageLeft to rightBalancedEC 3.1.4.38cytosol
Human-GEM MAR09805CC BY 4.0Reference data
sn-glycerol 3-phosphocholine+waterphosphocholine+glycerol+hydron
Catalysed by ENPP6
5 names
Resolves to: ENPP6
Rhea RHEA:19545CC BY 4.0Reference data
a 1-O-alkyl-sn-glycero-3-phosphocholine+watera 1-O-alkyl-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:36083CC BY 4.0Reference data
1-tetradecanoyl-sn-glycero-3-phosphocholine+water1-tetradecanoyl-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalanced
Rhea RHEA:40999CC BY 4.0Reference data
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalanced
Rhea RHEA:41003CC BY 4.0Reference data
1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-(9Z-octadecenoyl)-sn-glycerol+phosphocholine+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:41091CC BY 4.0Reference data
sphing-4-enine-phosphocholine+watersphing-4-enine+phosphocholine+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalanced
Rhea RHEA:41095CC BY 4.0Reference data
1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine+water1-(9Z,12Z-octadecadienoyl)-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalanced
Rhea RHEA:41115CC BY 4.0Reference data
1-hexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycerol+phosphocholine+hydron
Catalysed by SMPD2 or ENPP6 or ENPP7 or SMPD3
Reaction pageLeft to rightBalanced
Rhea RHEA:41119CC BY 4.0Reference data
1-dodecanoyl-sn-glycero-3-phosphocholine+water1-dodecanoyl-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalanced
Rhea RHEA:41127CC BY 4.0Reference data
a 1-acyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycerol+phosphocholine+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:44720CC BY 4.0Reference data
glycero-2-phosphocholine+waterphosphocholine+glycerol+hydron
Catalysed by ENPP6
Reaction pageLeft to rightBalanced
Rhea RHEA:61684CC BY 4.0Reference data