propionyl-CoA

Three steps

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatus

• leukotriene C4Reach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. leukotriene C4 hydrolysis

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• taurocyamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by ACOT7, BAAT, GATMcytosol

• L-cysteateReach from here →
  1. Propanoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. L-cysteate + H(+) = taurine + CO2

  Catalysed by ACOT7, BAAT, GADL1, CSADcytosol

• L-phenylalanineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 30 routes

• N(1)-acetylspermineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2

  Catalysed by ACOT7, SAT1, SAT2, PAOXcytosol

• 3-hydroxy-L-kynurenineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by ACOT7, KYNUcytosol, mitochondrial matrix

• gamma-L-glutamyl-L-cysteineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by ACOT7, NAGS, GCLC, GCLMcytosol, mitochondrial matrixOne of 2 routes

• L-homocysteineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-homocysteine + L-serine = L,L-cystathionine + H2O

  Catalysed by ACOT7, NAGS, CBScytosol, mitochondrial matrixOne of 2 routes

• S-methyl-L-methionineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by ACOT7, NAGS, BHMT2cytosol, mitochondrial matrix

• N-acetylputrescineReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space

• 3-oxosphinganineReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 8 morecytosol

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol, peroxisome

• L-tyrosineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• N(1)-acetylspermidineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. spermidine + acetyl-CoA = N(1)-acetylspermidine + CoA + H(+)

  Catalysed by ACOT7, SAT1, SAT2cytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• 3-aminopropanalReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermine)
  3. spermidine:oxygen oxidoreductase (spermidine-forming)

  Catalysed by ACOT7, SAT1, SAT2, SMOXcytosol

• trans-4-hydroxy-L-prolineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by ACOT7, SLC1A4cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• N(8)-acetylspermidineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N8-acetylspermidine to spermidine conversion

  Catalysed by ACOT7, SAT1, SAT2cytosolOne of 4 routes

• N(1),N(12)-diacetylspermineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N1,N12-diacetylspermine to N1-acetylspermine conversion
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ACOT7cytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 8 morecytosolOne of 2 routes

• S-sulfanyl-L-cysteineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by ACOT7, NAGS, CARS2cytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 14 morecytosol, Golgi apparatus

• (3S)-citramalyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)
  3. (3S)-citramalyl-CoA = itaconyl-CoA + H2O

  Catalysed by ACOT7, SUCLG1, SUCLG2, SUCLA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• phosphoenolpyruvateReach from here →
  1. Propanoyl-CoA hydrolase
  2. ATP citrate lyase (citrate)
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by ACOT7, ACLY, PCK1, PCK2cytosol

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by ACOT7, NAGS, MSRAcytosol, mitochondrial matrix

• L-methionine (R)-S-oxideReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by ACOT7, NAGS, MSRB3, MSRB1 and 1 morecytosol, mitochondrial matrix

• 5-amino-2-oxopentanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 3 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by ACOT7, NAGS, PPCScytosol, mitochondrial matrixOne of 4 routes

• 4-aminobutanoateReach from here →
  1. Active Transport
  2. Carnitine Transport by Atb0
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• L-prolineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by ACOT7, SLC1A4cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• sphing-4-enine 1-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + ATP = sphing-4-enine 1-phosphate + ADP + H(+)

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 3 morecytosol, Golgi apparatus

• N-benzoylglycineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 2 routes

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. Active Transport
  2. Utilized Transport
  3. linoleate:oxygen 9-oxidoreductase

  No catalyst recordedmitochondrial matrix, cytosol, endoplasmic reticulum

• 3-sulfino-L-alanineReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by ACOT7, NAGS, CDO1cytosol, mitochondrial matrixOne of 2 routes

• (2E)-tetradecenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. trans-tetradec-2-enoyl-CoA reductase

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol, mitochondrial matrixOne of 5 routes

• (2E)-decenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. trans-dec-2-enoyl-CoA reductase

  Catalysed by ACOT7, ACSM4, ACSM1, ACSM2A and 4 morecytosol, mitochondrial matrixOne of 8 routes

• L-cysteinylglycineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ACOT7, GGTLC3, GGT1, GGT5 and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (2E)-hexenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (hexanoic acid)
  3. trans-hex-2-enoyl-CoA reductase

  Catalysed by ACOT7, ACSM4, ACSM1, ACSM2A and 4 morecytosol, mitochondrial matrixOne of 3 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• a cardiolipinReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus

• (2E)-octenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. trans-oct-2-enoyl-CoA reductase

  Catalysed by ACOT7, CROT, MECRcytosol, mitochondrial matrixOne of 5 routes

• 3-oxotetradecanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• an all-trans-retinyl esterReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatusOne of 4 routes

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Active Transport
  2. Utilized Transport
  3. cytochrome P450 (arachidonate)

  Catalysed by CYP4F8mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• 1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatus