Compound

(2E)-hexenoyl-CoA

An acyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate OH groups of trans-hex-2-enoyl-CoA; major species at pH 7.3.

Definition from ChEBI (CHEBI:62077), read 2026-09-23. CC BY 4.0.

CHEBI:62077ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C27H40N7O17P3S
Mass: 859.638 g/mol
Charge: -4
InChIKey: OINXHIBNZUUIMR-IXUYQXAASA-J
SMILES: CCC/C=C/C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

8 entities

8 entities reached.

0 reported hops8 assembled from the scaffold

What the reference databases state

Statements

24 statements

24 statements · 2 reference databases · Subject: (2E)-hexenoyl-CoA · Sources: Human-GEM, Rhea

Order

(2E)-hexenoyl-CoA is converted to CHEBI:27540CompoundHuman-GEM MAR02207Inferred only
CHEBI:27540 is converted to (2E)-hexenoyl-CoACompoundHuman-GEM MAR02207Inferred only
CHEBI:27540 is converted to (2E)-hexenoyl-CoACompoundHuman-GEM MAR03098Inferred only
CHEBI:27540 is converted to (2E)-hexenoyl-CoACompoundHuman-GEM MAR03156Inferred only
hexanoyl-CoA is converted to (2E)-hexenoyl-CoACompoundRhea RHEA:31207Inferred only
hexanoyl-CoA is converted to (2E)-hexenoyl-CoACompoundRhea RHEA:40311Inferred only
hexanoyl-CoA is converted to (2E)-hexenoyl-CoACompoundRhea RHEA:52576Inferred only
(2E)-hexenoyl-CoA is converted to hexanoyl-CoACompoundRhea RHEA:31207Inferred only
(2E)-hexenoyl-CoA is converted to hexanoyl-CoACompoundRhea RHEA:44956Inferred only
(2E)-hexenoyl-CoA is converted to hexanoyl-CoACompoundRhea RHEA:52576Inferred only
(2E)-hexenoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR06280Inferred only
(2E)-hexenoyl-CoA is a substrate of ECHS1ProteinRhea RHEA:30547Inferred only

Show the remaining 12

(2E)-hexenoyl-CoA is a substrate of ECHS1ProteinHuman-GEM MAR03157Inferred only
(2E)-hexenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03099Inferred only
(2E)-hexenoyl-CoA is a substrate of ECI2ProteinHuman-GEM MAR03099Inferred only
(2E)-hexenoyl-CoA is a substrate of EHHADHProteinRhea RHEA:30547Inferred only
(2E)-hexenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR03099Inferred only
(2E)-hexenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR06280Inferred only
(2E)-hexenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03157Inferred only
(2E)-hexenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03099Inferred only
(2E)-hexenoyl-CoA is a substrate of HADHAProteinRhea RHEA:30547Inferred only
(2E)-hexenoyl-CoA is a substrate of HSD17B4ProteinHuman-GEM MAR06280Inferred only
(2E)-hexenoyl-CoA is a substrate of MECRProteinHuman-GEM MAR02207Inferred only
(2E)-hexenoyl-CoA is a substrate of PECRProteinRhea RHEA:44956Inferred only

Reactions

17 reactions

(2E)-hexenoyl-CoA+proton+NADPH(4-)CHEBI:27540+NADP(3-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02207CC BY 4.0Reference data
FAD+CHEBI:27540(2E)-hexenoyl-CoA+FADH2
Catalysed by ACOX3 or ACOX1
Reaction pageLeft to rightBalancedEC 1.3.3.6peroxisome
Human-GEM MAR03098CC BY 4.0Reference data
(2E)-hexenoyl-CoA+waterMAM00182x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03099CC BY 4.0Reference data
FAD+CHEBI:27540(2E)-hexenoyl-CoA+FADH2
Catalysed by ACOX3 or ACOX1 or ACADSB
Reaction pageLeft to rightBalancedEC 1.3.8.5, 1.3.3.6mitochondrial matrix
Human-GEM MAR03156CC BY 4.0Reference data
(2E)-hexenoyl-CoA+waterMAM00182m
Catalysed by HADHA or ECHS1
Reaction pageLeft to rightBalancedEC 4.2.1.17mitochondrial matrix
Human-GEM MAR03157CC BY 4.0Reference data
(2E)-hexenoyl-CoA+CHEBI:1146900+water+NAD(+)CHEBI:15351+butanoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedperoxisome
Human-GEM MAR06280CC BY 4.0Reference data
MAM03659m(2E)-hexenoyl-CoA
Catalysed by ECI1
Reaction pageLeft to rightBalancedEC 5.3.3.8mitochondrial matrix
Human-GEM MAR06281CC BY 4.0Reference data
MAM03659x(2E)-hexenoyl-CoA
Catalysed by EHHADH or ECI2
Reaction pageLeft to rightBalancedperoxisome
Human-GEM MAR06282CC BY 4.0Reference data
CHEBI:62075(2E)-hexenoyl-CoA+water
Catalysed by ECHS1 or HADHA or EHHADH
Reaction pageRight to leftBalanced
Rhea RHEA:30547CC BY 4.0Reference data
hexanoyl-CoA+FAD(3-)+hydron(2E)-hexenoyl-CoA+FADH2(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:31207CC BY 4.0Reference data
hexanoyl-CoA+dioxygen(2E)-hexenoyl-CoA+hydrogen peroxide
Catalysed by ACOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:40311CC BY 4.0Reference data
hexanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydron(2E)-hexenoyl-CoA+reduced [electron-transfer flavoprotein]
Catalysed by ACADM or ACADS or IVD or ACADL or ACADSB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:43464CC BY 4.0Reference data

Show the remaining 5

Other names

8 names

Resolves to: (2E)-hexenoyl-CoA

Also called: (2E)-hexenoyl-CoA(4-)(2E)-hexenoyl-CoA(4−)(2E)-hexenoyl-coenzyme A(4-)(2E)-hexenoyl-coenzyme A(4−)hexenoyl-CoA(4-)hexenoyl-CoA(4−)trans-hex-2-enoyl-coenzyme A(4-)trans-hex-2-enoyl-coenzyme A(4−)