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Proteins/UNIPROT:Q9BV79
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates. May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism. Required for proper morphology and bioenergetic functions of mitochondria. Required for maintenance of neurons (By similarity)..
Function from UniProtKB (Q9BV79), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
30 statements
30 statements · 4 reference databases · Subject: MECR · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
15 reactions
NADP(3-)+palmitoyl-CoA(2E)-hexadecenoyl-CoA+proton+NADPH(4-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02028CC BY 4.0Reference data
NADP(3-)+octanoyl-CoA(2E)-octenoyl-CoA+proton+NADPH(4-)
Catalysed by MECR
5 names
Resolves to: MECR
Human-GEM MAR02148CC BY 4.0Reference data
dodecanoyl-CoA+NADP(3-)(2E)-dodecenoyl-CoA+proton+NADPH(4-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02149CC BY 4.0Reference data
MAM01409c+proton+NADPH(4-)MAM01411c+NADP(3-)
Catalysed by PECR or MECR or FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85, 1.3.1.39cytosol
Human-GEM MAR02155CC BY 4.0Reference data
tetradecanoyl-CoA+NADP(3-)(2E)-tetradecenoyl-CoA+proton+NADPH(4-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02183CC BY 4.0Reference data
decanoyl-CoA+NADP(3-)(2E)-decenoyl-CoA+proton+NADPH(4-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02187CC BY 4.0Reference data
(2E)-hexenoyl-CoA+proton+NADPH(4-)CHEBI:27540+NADP(3-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02207CC BY 4.0Reference data
a 2,3-saturated acyl-[ACP]+NADP(3-)a (2E)-enoyl-[ACP]+NADPH(4-)+hydron
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:22564CC BY 4.0Reference data
(2E)-butenoyl-[ACP]+NADPH(4-)+hydronbutanoyl-[ACP]+NADP(3-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41812CC BY 4.0Reference data
(2E)-hexenoyl-[ACP]+NADPH(4-)+hydronhexanoyl-[ACP]+NADP(3-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41832CC BY 4.0Reference data
(2E)-octenoyl-[ACP]+NADPH(4-)+hydronoctanoyl-[ACP]+NADP(3-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41848CC BY 4.0Reference data
(2E)-decenoyl-[ACP]+NADPH(4-)+hydrondecanoyl-[ACP]+NADP(3-)
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41864CC BY 4.0Reference data