(2E)-hexenoyl-CoA

1. trans-hex-2-enoyl-CoA reductase

Catalysed by MECRmitochondrial matrix

1. Fatty Acid Beta Oxidation (C6:1->C4:0), Peroxisomal

Catalysed by ACAA1, HSD17B4, EHHADHperoxisome

1. (2E)-hexenoyl-CoA + NADPH + H(+) = hexanoyl-CoA + NADP(+)

Catalysed by PECR

1. Fatty Acid Beta Oxidation (C6:1->C4:0), Peroxisomal
2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)

Catalysed by ACAA1, HSD17B4, EHHADH, SLC33A1 and 2 moreperoxisome, mitochondrial matrix, cytosolOne of 2 routes

1. trans-hex-2-enoyl-CoA reductase
2. Production of Hexanoylcarnitine

Catalysed by MECR, CPT1A, CPT1C, CPT1B

1. Fatty Acid Beta Oxidation (C6:1->C4:0), Peroxisomal
2. Butyryl-CoA hydrolase
3. transport of 2-hydroxybutyrate and butyrate (cytosol to extracellular)

Catalysed by ACAA1, HSD17B4, EHHADH, ACOT12 and 4 moreperoxisome, cytosol, extracellular spaceOne of 2 routes

1. Fatty Acid Beta Oxidation (C6:1->C4:0), Peroxisomal
2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
3. carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)