Compound

(2E)-octenoyl-CoA

A trans-2,3-didehydroacyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate OH groups of trans-oct-2-enoyl-CoA; major species at pH 7.3.

Definition from ChEBI (CHEBI:62242), read 2026-09-23. CC BY 4.0.

CHEBI:62242ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C29H44N7O17P3S
Mass: 887.692 g/mol
Charge: -4
InChIKey: CPSDNAXXKWVYIY-NTLMCJQISA-J
SMILES: CCCCC/C=C/C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

7 entities

7 entities reached.

0 reported hops7 assembled from the scaffold

What the reference databases state

Statements

20 statements

20 statements · 2 reference databases · Subject: (2E)-octenoyl-CoA · Sources: Human-GEM, Rhea

Order

(2E)-octenoyl-CoA is converted to octanoyl-CoACompoundHuman-GEM MAR02148Inferred only
(2E)-octenoyl-CoA is converted to octanoyl-CoACompoundRhea RHEA:44952Inferred only
(2E)-octenoyl-CoA is converted to octanoyl-CoACompoundRhea RHEA:63232Inferred only
octanoyl-CoA is converted to (2E)-octenoyl-CoACompoundHuman-GEM MAR02148Inferred only
octanoyl-CoA is converted to (2E)-octenoyl-CoACompoundHuman-GEM MAR03094Inferred only
octanoyl-CoA is converted to (2E)-octenoyl-CoACompoundHuman-GEM MAR03149Inferred only
octanoyl-CoA is converted to (2E)-octenoyl-CoACompoundRhea RHEA:30943Inferred only
octanoyl-CoA is converted to (2E)-octenoyl-CoACompoundRhea RHEA:40175Inferred only
(2E)-octenoyl-CoA is converted to octanoyl-CoACompoundRhea RHEA:30943Inferred only
octanoyl-CoA is converted to (2E)-octenoyl-CoACompoundRhea RHEA:63232Inferred only
(2E)-octenoyl-CoA is a substrate of ECHS1ProteinHuman-GEM MAR03150Inferred only
(2E)-octenoyl-CoA is a substrate of ECI1ProteinHuman-GEM MAR03095Inferred only

Show the remaining 8

(2E)-octenoyl-CoA is a substrate of ECI2ProteinHuman-GEM MAR03095Inferred only
(2E)-octenoyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR03095Inferred only
(2E)-octenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03095Inferred only
(2E)-octenoyl-CoA is a substrate of HADHAProteinRhea RHEA:31199Inferred only
(2E)-octenoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03150Inferred only
(2E)-octenoyl-CoA is a substrate of HSD17B4ProteinRhea RHEA:40187Inferred only
(2E)-octenoyl-CoA is a substrate of MECRProteinHuman-GEM MAR02148Inferred only
(2E)-octenoyl-CoA is a substrate of PECRProteinRhea RHEA:44952Inferred only

Reactions

15 reactions

NADP(3-)+octanoyl-CoA(2E)-octenoyl-CoA+proton+NADPH(4-)
Catalysed by MECR
Reaction pageReversibleBalancedEC 1.3.1.38mitochondrial matrix
Human-GEM MAR02148CC BY 4.0Reference data
FAD+octanoyl-CoA(2E)-octenoyl-CoA+FADH2
Catalysed by ACOX3 or ACOX1
Reaction pageLeft to rightBalancedEC 1.3.3.6peroxisome
Human-GEM MAR03094CC BY 4.0Reference data
(2E)-octenoyl-CoA+waterMAM00183x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03095CC BY 4.0Reference data
FAD+octanoyl-CoA(2E)-octenoyl-CoA+FADH2
Catalysed by ACOX3 or ACOX1 or ACADM or ACAD9
Reaction pageLeft to rightBalancedEC 1.3.8.7, 1.3.99.-, 1.3.3.6mitochondrial matrix
Human-GEM MAR03149CC BY 4.0Reference data
(2E)-octenoyl-CoA+waterMAM00183m
Catalysed by HADHA or ECHS1
Reaction pageLeft to rightBalancedEC 4.2.1.17mitochondrial matrix
Human-GEM MAR03150CC BY 4.0Reference data
octanoyl-CoA+FAD(3-)+hydron(2E)-octenoyl-CoA+FADH2(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:30943CC BY 4.0Reference data
CHEBI:62617(2E)-octenoyl-CoA+water
Catalysed by HADHA
Reaction pageRight to leftBalanced
Rhea RHEA:31199CC BY 4.0Reference data
octanoyl-CoA+dioxygen(2E)-octenoyl-CoA+hydrogen peroxide
Catalysed by ACOX1
Reaction pageLeft to rightBalanced
Rhea RHEA:40175CC BY 4.0Reference data
(2E)-octenoyl-CoA+waterCHEBI:74279
Catalysed by HSD17B4
Reaction pageLeft to rightBalanced
Rhea RHEA:40187CC BY 4.0Reference data
(2E)-octenoyl-CoA+NADPH(4-)+hydronoctanoyl-CoA+NADP(3-)
Catalysed by PECR
Reaction pageLeft to rightBalanced
Rhea RHEA:44952CC BY 4.0Reference data
CHEBI:85640(2E)-octenoyl-CoA
Catalysed by ECI2 or ECI1
Reaction pageLeft to rightBalanced
Rhea RHEA:46044CC BY 4.0Reference data
(2E)-octenoyl-CoA+waterCHEBI:86040
Reaction pageDirection not assertedBalanced
Rhea RHEA:46348CC BY 4.0Reference data

Show the remaining 3

Other names

10 names

Resolves to: (2E)-octenoyl-CoA

Also called: (2E)-octenoyl-CoA(4-)(2E)-octenoyl-CoA(4−)(2E)-octenoyl-coenzyme A(4-)(2E)-octenoyl-coenzyme A(4−)trans-2-octenoyl-coenzyme A(4-)trans-2-octenoyl-coenzyme A(4−)trans-2,3-didehydroacyl-CoA (C8)(4-)trans-2,3-didehydroacyl-CoA (C8)(4−)trans-oct-2-enoyl-coenzyme A(4-)trans-oct-2-enoyl-coenzyme A(4−)