prostaglandin J2

Three steps

• lithocholic acidReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of lithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• oxaloacetateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by LDHB, LDHAL6B, PCextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by SLCO2A1, CNDP2cytosol, inner side of the membrane, outer side of the membrane

• 2-oxobutanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by LDHB, LDHAL6B, KYAT1extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by LDHB, LDHAL6B, FAHD1extracellular space, cytosol, mitochondrial matrix

• bilirubin IXalphaReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of bilirubin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• taurolithocholateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 3-hydroxypyruvateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXTextracellular space, cytosol, mitochondrial matrix

• CHEBI:17208Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by SLCO2A1cytosol, extracellular spaceOne of 2 routes

• homocysteineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by SLCO2A1cytosol, extracellular space

• 17alpha-hydroxyprogesteroneReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol, endoplasmic reticulum

• aceneuramateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by LDHB, LDHAL6B, NPLextracellular space, cytosol, mitochondrial matrix

• 5'-deoxyadenosineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by LDHB, LDHAL6B, TYW1B, TYW1extracellular space, cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. cystine to cysteine conversion

  Catalysed by SLCO2A1cytosol, extracellular space

• xanthineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by SLC22A12, XDHextracellular space, cytosolOne of 2 routes

• 4-methylumbelliferyl acetateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 5 moreextracellular space, cytosol

• all-trans-retinalReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of L-lactate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 moreextracellular space, cytosol

• 4-fumarylacetoacetateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetoacetate and L-lactate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• 5-hydroxyisourateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. urate:oxygen oxidoreductase

  Catalysed by SLC22A12extracellular space, cytosol

• dTDPReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by LDHB, LDHAL6B, PKM, PKLRextracellular space, cytosol, mitochondrial matrix

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• (S)-lactoyl-AMPReach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by SLCO2A1, AARS1, AARS2cytosol, inner side of the membrane, outer side of the membrane

• (S)-lactoyl-CoAReach from here →
  1. prostaglandin J2 hydrolysis
  2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by SLCO2A1, ACSS2cytosol, inner side of the membrane, outer side of the membrane

• 5(S)-HETEReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO2A1, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:28666Reach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of LTD4 (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol, endoplasmic reticulum

• a dicarboxylateReach from here →
  1. prostaglandin J2 hydrolysis
  2. aldo-keto reductase (prostaglandin D2)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by AKR1C3, SLC22A6cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• chlorine(.)Reach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of formate and L-lactate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• cholateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 3-hydroxypyruvic acidReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by LDHB, LDHAL6B, AGXTextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• glutarateReach from here →
  1. prostaglandin J2 hydrolysis
  2. aldo-keto reductase (prostaglandin D2)
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by AKR1C3, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by SLCO1B1cytosol, extracellular spaceOne of 4 routes

• nicotinateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of L-lactate and urate (cytosol to extracellular)
  3. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by SLC22A12, SLC22A13extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 3-oxopropanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by LDHB, LDHAL6B, AGXT2extracellular space, cytosol, mitochondrial matrix

• serotoninReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• D-serineReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by LDHB, LDHAL6B, SRRextracellular space, cytosol, mitochondrial matrix

• chenodeoxycholateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• taurocholateReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• glycolithocholic acidReach from here →
  1. prostaglandin J2 hydrolysis
  2. transport of prostaglandin D2 (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (R)-lactic acidReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by LDHB, LDHAL6B, LDHDextracellular space, cytosol, mitochondrial matrix

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of acetoacetate and L-lactate (cytosol to extracellular)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol

• 2-iminopropanoateReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by LDHB, LDHAL6B, RIDAextracellular space, cytosol, mitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by LDHB, LDHAL6B, PKM, PKLRextracellular space, cytosol, mitochondrial matrix

• 13-cis-retinalReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. transport of L-lactate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. Transport of Prostaglandin J2, Lactate Antiport
  2. (S)-Lactate:NAD+ oxidoreductase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by LDHB, LDHAL6B, NPLextracellular space, cytosol, mitochondrial matrix