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Proteins/UNIPROT:Q5JTZ9
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS. Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated..
Function from UniProtKB (Q5JTZ9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
12 statements
12 statements · 6 reference databases · Subject: AARS2 · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
3 reactions
CHEBI:78442+L-alanine+ATP(4-)CHEBI:78497+AMP+diphosphate(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:12540CC BY 4.0Reference data
(S)-lactate+ATP(4-)+hydron(S)-lactoyl-AMP+diphosphate(3-)
Catalysed by AARS1
6 names
Resolves to: AARS2
Reaction pageLeft to rightBalanced
Rhea RHEA:80271CC BY 4.0Reference data
(S)-lactoyl-AMP+L-lysyl-[protein]N(6)-[(S)-lactoyl]-L-lysyl-[protein]+AMP+2hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:80275CC BY 4.0Reference data