N-tetradecanoylglycine

Three steps

• CHEBI:16633Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by GLYATL2, SLC7A5, MARS1extracellular space, cytosol

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by PAM, AADATOne of 2 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by GLYATL2, SLC7A5, CNDP2extracellular space, cytosol

• 9-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 9-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GLYATL2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 10-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GLYATL2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 12-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 12-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GLYATL2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 11-hydroxytetradecanoateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Myristoyl-CoA hydrolase
  3. tetradecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 11-hydroxytetradecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by GLYATL2, ACOT7, BAAT, THEM4 and 3 morecytosol

• 2-oxobutanoateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by PAM, AGXT2One of 5 routes

• tryptamineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by GLYATL2, SLC7A5, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by GLYATL2, SLC7A5, KYAT1extracellular space, cytosolOne of 3 routes

• formaldehydeReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. sarcosine:oxygen oxidoreductase (demethylating)

  Catalysed by GLYATL2, GNMT, PIPOX, SARDHcytosol, peroxisomeOne of 2 routes

• creatineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase

  Catalysed by GLYATL2, GATM, GAMTcytosolOne of 2 routes

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)
  3. 1-acylglycerol-3P-LD-TG1 pool (liver tissue) formation

  Catalysed by GLYATL2, GPAT3, GPAT2, GPAT4 and 1 morecytosolOne of 9 routes

• bilirubin IXalphaReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by GLYATL2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• oxalic acidReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. glycine:oxygen oxidoreductase (deaminating)
  3. Glyoxylate:oxygen oxidoreductase

  Catalysed by GLYATL2, DAO, HAO1peroxisomeOne of 3 routes

• a cholesterol esterReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by GLYATL2, SOAT2, SOAT1cytosol

• taurolithocholateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by GLYATL2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• homocysteineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Formation of Homocystine

  Catalysed by GLYATL2, GSScytosol

• L-glutamic 5-semialdehydeReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. L-Arginine:glycine amidinotransferase
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by GLYATL2, GATM, OATcytosol, mitochondrial matrix

• anilineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by GLYATL2, BAAT, NAT2, NAT1peroxisome, cytosol

• CHEBI:17312Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by GLYATL2, BAATperoxisome, cytosolOne of 2 routes

• sulfiteReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GLYATL2, GSS, TSTD1One of 2 routes

• CHEBI:17380Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by GLYATL2, SLC7A5extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by GLYATL2, SLC7A5, SLC7A6, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by GLYATL2, SLC7A6extracellular space, cytosol, mitochondrial matrix

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by GLYATL2, LPCAT4, LPCAT3, LPCAT2 and 1 morecytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. fatty-acyl-CoA synthase (N-C16:0CoA)
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by GLYATL2, CPT2, CPT1Acytosol, peroxisomeOne of 4 routes

• AH2Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosolOne of 4 routes

• indole-3-pyruvateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by PAM, AADATOne of 3 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by GLYATL2, BAAT, HADHA, ACADVL and 1 moreperoxisome, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by GLYATL2, GNMT, PDPR, DMGDHcytosol

• Ala-tRNA(Ala)Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol

• glycine betaineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by GLYATL2, SLC6A9, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by GLYATL2, SLC7A6, HALextracellular space, cytosol

• urateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by PAMcytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GLYATL2, SLC7A5, TPH1, TPH2extracellular space, cytosol

• a 1,2-diacyl-sn-glycerolReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by GLYATL2, MOGAT2, AWAT2, MOGAT1cytosol

• methylarsonous acidReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GLYATL2, GSS, GSTO1, GSTO2

• a triacylglycerolReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. acyl-CoA pool formation and breakdown
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by GLYATL2, DGAT1, MOGAT2, MOGAT3 and 2 morecytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by PAM, AADATOne of 5 routes

• CHEBI:17927Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. bile acid-CoA: amino acid N-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by GLYATL2, BAATperoxisome, cytosolOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by PAM, AADATOne of 6 routes

• CHEBI:18095Reach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by GLYATL2, SLC6A9, SLC6A14, CLTRN and 1 moreextracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by GLYATL2, SLC6A9, SLC6A14extracellular space, cytosolOne of 2 routes

• dodecanoateReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. Fatty Acid Beta Oxidation (C14->C12), Mitochondrial
  3. Lauroyl-CoA hydrolase

  Catalysed by GLYATL2, HADHA, ACADVL, HADHB and 4 moremitochondrial matrix, cytosolOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by GLYATL2, GARTcytosol

• arsenic triglutathioneReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by GLYATL2, GSS, AS3MTOne of 3 routes

• 2-phenylethylamineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by GLYATL2, SLC7A5, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by GLYATL2, SLC7A5, PFASextracellular space, cytosol