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Proteins/UNIPROT:Q5T1C6

THEM4

Protein·UNIPROT:Q5T1C6Acyl-coenzyme A thioesterase THEM4

Open in the graph

Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane..

Function from UniProtKB (Q5T1C6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

58 statements

58 statements · 6 reference databases · Subject: THEM4 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

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C11orf24 covaries with THEM4ProteinHetionet hetionet:covaries:117145-53838Inferred only
AKT1 interacts with THEM4ProteinHetionet hetionet:interacts:117145-207Inferred only
THEM4 participates in Activation of AKT2PathwayReactome R-HSA-165158Inferred only
THEM4 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
THEM4 participates in CD28 dependent PI3K/Akt signalingPathwayReactome R-HSA-389357Inferred only
THEM4 participates in Co-stimulation by CD28PathwayReactome R-HSA-389356Inferred only
THEM4 participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
THEM4 participates in IGF1R signaling cascadePathwayReactome R-HSA-2428924Inferred only
THEM4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
THEM4 participates in Insulin receptor signalling cascadePathwayReactome R-HSA-74751Inferred only
THEM4 participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
THEM4 participates in IRS-mediated signallingPathwayReactome R-HSA-112399Inferred only

Show the remaining 46

THEM4 participates in IRS-related events triggered by IGF1RPathwayReactome R-HSA-2428928Inferred only
THEM4 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
THEM4 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
THEM4 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
THEM4 participates in Mitochondrial Fatty Acid Beta-OxidationPathwayReactome R-HSA-77289Inferred only
THEM4 participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
THEM4 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
THEM4 participates in PI3K CascadePathwayReactome R-HSA-109704Inferred only
THEM4 participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
THEM4 participates in Regulation of T cell activation by CD28 familyPathwayReactome R-HSA-388841Inferred only
THEM4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
THEM4 participates in Signaling by Insulin receptorPathwayReactome R-HSA-74752Inferred only
THEM4 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
THEM4 participates in Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)PathwayReactome R-HSA-2404192Inferred only
THEM4 participates in Signaling by VEGFPathwayReactome R-HSA-194138Inferred only
THEM4 participates in VEGFA-VEGFR2 PathwayPathwayReactome R-HSA-4420097Inferred only
THEM4 participates in VEGFR2 mediated vascular permeabilityPathwayReactome R-HSA-5218920Inferred only
THEM4 regulates negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology Q5T1C6|GO:0051898Inferred only
THEM4 regulates regulation of mitochondrial membrane permeability involved in apoptotic processBiological processgene ontology Q5T1C6|GO:1902108Inferred only
(11Z)-docosenoyl-CoA(4-) is a substrate of THEM4CompoundHuman-GEM MAR00324Inferred only
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00426Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA is a substrate of THEM4CompoundRhea RHEA:40151Inferred only
(5Z)-tetradecenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00210Inferred only
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00354Inferred only
(6Z,9Z,12Z)-octadecatrienoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00402Inferred only
(7Z)-hexadecenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00234Inferred only
(7Z)-octadecenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00272Inferred only
(7Z)-tetradecenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00206Inferred only
(8Z,11Z,14Z)-eicosatrienoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00406Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00398Inferred only
(9Z,12Z)-octadecadienoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00276Inferred only
(9Z)-heptadecenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00246Inferred only
(9Z)-hexadecenoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00230Inferred only
(9Z)-octadecenoyl-CoA is a substrate of THEM4CompoundRhea RHEA:40139Inferred only
arachidonoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00410Inferred only
decanoyl-CoA is a substrate of THEM4CompoundRhea RHEA:40059Inferred only
dodecanoyl-CoA is a substrate of THEM4CompoundRhea RHEA:30135Inferred only
heptadecanoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00238Inferred only
hexadecanoyl-CoA is a substrate of THEM4CompoundRhea RHEA:16645Inferred only
octadecanoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00250Inferred only
octanoyl-CoA is a substrate of THEM4CompoundRhea RHEA:30143Inferred only
oleoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00264Inferred only
palmitoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00223Inferred only
tetracosanoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00332Inferred only
tetradecanoyl-CoA is a substrate of THEM4CompoundHuman-GEM MAR00197Inferred only
tetradecanoyl-CoA is a substrate of THEM4CompoundRhea RHEA:40119Inferred only

Reactions

34 reactions

water+tetradecanoyl-CoACHEBI:1146900+proton+tetradecanoate
Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00197CC BY 4.0Reference data
MAM00129c+waterMAM00128c+

Other names

4 names

Resolves to: THEM4

Also called: Acyl-CoA thioesterase THEM4Carboxyl-terminal modulator proteinCTMPThioesterase superfamily member 4

← Every protein Find it in the graph →

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00201CC BY 4.0Reference data

(7Z)-tetradecenoyl-CoA+waterMAM00117c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00206CC BY 4.0Reference data

(5Z)-tetradecenoyl-CoA+waterCHEBI:1146900+proton+MAM02745c

Catalysed by ACOT1 or ACOT7 or BAAT or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00210CC BY 4.0Reference data

water+MAM02689cCHEBI:1146900+proton+MAM02690c

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00214CC BY 4.0Reference data

water+palmitoyl-CoACHEBI:1146900+proton+hexadecanoic acid

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00223CC BY 4.0Reference data

water+(9Z)-hexadecenoyl-CoACHEBI:1146900+proton+(9Z)-hexadecenoate

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00230CC BY 4.0Reference data

(7Z)-hexadecenoyl-CoA+waterMAM01197c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00234CC BY 4.0Reference data

water+heptadecanoyl-CoACHEBI:1146900+proton+MAM02456c

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00238CC BY 4.0Reference data

MAM00004c+waterMAM00003c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00242CC BY 4.0Reference data

(9Z)-heptadecenoyl-CoA+waterMAM01238c+CHEBI:1146900+proton

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00246CC BY 4.0Reference data

water+octadecanoyl-CoACHEBI:1146900+proton+octadecanoate

Catalysed by ACOT1 or ACOT7 or BAAT or ACOT13 or THEM4

Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol

Human-GEM MAR00250CC BY 4.0Reference data

Show the remaining 22