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Proteins/UNIPROT:Q86VF5
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG)..
Function from UniProtKB (Q86VF5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
34 statements
34 statements · 6 reference databases · Subject: MOGAT3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
10 reactions
a 1,2-diacyl-sn-glycerol+an acyl-CoACHEBI:1146900+a triacylglycerol
Catalysed by DGAT2 or MOGAT3 or MOGAT1 or MOGAT2 or DGAT1
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.20, 2.3.1.22cytosol
Human-GEM MAR00605CC BY 4.0Reference data
8 names
Resolves to: MOGAT3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10868CC BY 4.0Reference data
a 2-acylglycerol+an acyl-CoAa 1,2-diacylglycerol+coenzyme A(4-)
Catalysed by MOGAT2 or MOGAT3 or LPGAT1 or TMEM68 or MOGAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16741CC BY 4.0Reference data
2-(9Z-octadecenoyl)-glycerol+(9Z)-octadecenoyl-CoA1,2-di-(9Z-octadecenoyl)-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:37911CC BY 4.0Reference data
2-(9Z-octadecenoyl)-glycerol+hexadecanoyl-CoA1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or AWAT2 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38071CC BY 4.0Reference data
all-trans-retinol+hexadecanoyl-CoAall-trans-retinyl hexadecanoate+coenzyme A(4-)
Catalysed by DGAT1 or PNPLA4 or AWAT2 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38175CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+(9Z)-octadecenoyl-CoA1,2,3-tri-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or AWAT1 or AWAT2 or DGAT2L6 or MOGAT3 or TMEM68 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:38219CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol+hexadecanoyl-CoA1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol+coenzyme A(4-)
Catalysed by MOGAT3
Reaction pageLeft to rightBalanced
Rhea RHEA:38299CC BY 4.0Reference data
1-O-(9Z-octadecenyl)-glycerol+(9Z)-octadecenoyl-CoA1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or AWAT2 or DGAT2L6 or MOGAT3 or DGAT2
Reaction pageLeft to rightBalanced
Rhea RHEA:55340CC BY 4.0Reference data
1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol+(9Z)-octadecenoyl-CoA1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol+coenzyme A(4-)
Catalysed by DGAT1 or MOGAT2 or MOGAT3
Reaction pageLeft to rightBalanced
Rhea RHEA:55344CC BY 4.0Reference data