L-tryptophan

Two steps

• trans-urocanateReach from here →
  1. transport of histidine and tryptophan (cytosol to extracellular)
  2. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC7A6, HALextracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of leucine and tryptophan (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A5, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by SLC7A6, SLC3A2extracellular space, cytosol

• 3-phenylpyruvateReach from here →
  1. transport of phenylalanine and tryptophan (cytosol to extracellular)
  2. Phenylalanine Transaminase, Mitochondrial

  Catalysed by SLC7A5, GOT2, TATextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• indole-3-acetaldehydeReach from here →
  1. L-tryptophan decarboxy-lyase
  2. Tryptamine:oxygen oxidoreductase(deaminating)

  Catalysed by DDC, AOC1, MAOA, MAOBcytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. Transport of Hydroxy-Proline

  Catalysed by SLC7A5, SLC1A4extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. Transport of 3-Ureidopropionate

  Catalysed by SLC6A14extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC7A5, GARTextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. transport of phenylalanine and tryptophan (cytosol to extracellular)
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC7A5, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of glutamine and tryptophan (cytosol to extracellular)
  2. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC7A5, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC7A5, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of methionine and tryptophan (cytosol to extracellular)
  2. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by SLC7A5, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-methyltryptamineReach from here →
  1. L-tryptophan decarboxy-lyase
  2. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by DDC, INMTcytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC7A5, AGXT2extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC7A5, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC7A5, CARS2extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC7A5, GLYAT, GLYATL2, GLYATL1extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. Peroxidase

  Catalysed by SLC6A14, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. transport of chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC12A2, SLC12A1extracellular space, cytosolOne of 3 routes

• phenylacetylglycineReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC7A5, GLYATextracellular space, cytosolOne of 3 routes

• CHEBI:28666Reach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. LTD4 hydrolysis

  Catalysed by SLC7A5extracellular space, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A5, SCLYextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC7A5, NAGSextracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A5, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC7A5, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. transport of phenylalanine and tryptophan (cytosol to extracellular)
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A5, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC7A5, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of isoleucine and tryptophan (cytosol to extracellular)
  2. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC7A5, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of glutamine and tryptophan (cytosol to extracellular)
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC7A5, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC7A9, SLC3A1, SLC7A6, LACC1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of asparagine and tryptophan (cytosol to extracellular)
  2. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC7A5, NARS1extracellular space, cytosol

• glycocholateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC7A5, CTHextracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
  2. arylformamidase (L-formylkynurenine)

  Catalysed by IDO1, TDO2, IDO2, AFMIDcytosolOne of 3 routes

• malonic acidReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. Malonate Transport, Antiport with Chloride

  Catalysed by SLC6A14extracellular space, cytosolOne of 2 routes

• L-lysineReach from here →
  1. transport of leucine and tryptophan (cytosol to extracellular)
  2. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by SLC7A5, SLC7A7extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. transport of ornithine and tryptophan (cytosol to extracellular)
  2. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. transport of arginine and tryptophan (cytosol to extracellular)
  2. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC7A6, SLC3A2, SLC7A7extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. transport of ornithine and tryptophan (cytosol to extracellular)
  2. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC7A13, CADinner side of the membrane, outer side of the membrane

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of methionine and tryptophan (cytosol to extracellular)
  2. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A5, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of cysteine and tryptophan (cytosol to extracellular)
  2. De novo synthesis of 2Fe2S

  Catalysed by SLC7A5, NDUFAB1, FDXR, FXN and 4 moreextracellular space, cytosol, mitochondrial matrix

• serotoninReach from here →
  1. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)
  2. 5-Hydroxy-L-tryptophan decarboxy-lyase

  Catalysed by TPH1, TPH2, DDCcytosolOne of 2 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of isoleucine and tryptophan (cytosol to extracellular)
  2. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC7A5, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. transport of alanine and tryptophan (cytosol to extracellular)
  2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. transport of glycine and tryptophan (cytosol to extracellular)
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC7A5, ALAS1, ALAS2extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. transport of isoleucine and tryptophan (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A5, BCAT1extracellular space, cytosolOne of 2 routes