dehydroepiandrosterone 3-sulfate

Three steps

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-hydroxyandrost-5-en-17-one + NADPH + H(+) = androst-5-en-3beta,17beta-diol + NADP(+)
  3. 3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)

  Catalysed by STS, AKR1B15, HSD17B3, HSD3B1 and 1 morecytosolOne of 6 routes

• iodideReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC26A4cytosol, extracellular spaceOne of 10 routes

• ubiquinonesReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by STS, SLC25A10, SDHD, SDHB and 2 morecytosol, mitochondrial matrix

• L-valineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 4 routes

• oxaloacetateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by STS, SLC25A10cytosol, mitochondrial matrixOne of 11 routes

• L-arginineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by STS, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membrane

• pregnenoloneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by STScytosol, Golgi apparatusOne of 4 routes

• (S)-lactateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 15 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3 and 1 moreextracellular space, cytosol

• dopamine quinoneReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• 3-fumarylpyruvateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by STS, SLC25A10, FAHD1cytosol, mitochondrial matrix

• CHEBI:16856Reach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 76 routes

• CHEBI:16857Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• ferrocytochrome cReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by STS, SLC25A14, SLC25A30, SUOXcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by STS, SLC25A14, SLC25A30, NAT8Lcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 5beta-androstane-3,17-dioneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
  3. androst-4-ene-3,17-dione + NADPH + H(+) = 5beta-androstane-3,17-dione + NADP(+)

  Catalysed by STS, HSD3B1, HSD3B2, AKR1D1cytosol, endoplasmic reticulum

• L-isoleucineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular spaceOne of 3 routes

• CHEBI:17208Reach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by SLC22A24, SLC22A8inner side of the membrane, outer side of the membrane, cytosol

• propanoyl-4'-phosphopantetheineReach from here →
  1. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)
  2. propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate
  3. propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by SLC22A9, ACSM3, ACSS3, ACSS2 and 4 moreinner side of the membrane, outer side of the membrane

• dehydroascorbic acidReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosol

• 17alpha-hydroxyprogesteroneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. 17alpha-Hydroxypregnenolone:NAD+ 3-oxidoreductase

  Catalysed by STS, CYP17A1, HSD3B1, HSD3B2cytosol, endoplasmic reticulumOne of 3 routes

• estroneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
  3. cytochrome P450 (4-androstene-3,17-dione)

  Catalysed by STS, HSD3B1, HSD3B2, CYP19A1cytosol, endoplasmic reticulumOne of 5 routes

• testosteroneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
  3. testosterone:NADP+ 17-oxidoreductase

  Catalysed by STS, HSD3B1, HSD3B2, HSD17B6 and 7 morecytosol, endoplasmic reticulumOne of 4 routes

• enol-oxaloacetateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by SLC22A24, SLC22A8, CPT2, CPT1A and 1 moreinner side of the membrane, outer side of the membraneOne of 3 routes

• L-cysteineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 2 moreextracellular space, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. Steryl-Sulfatase
  3. Steryl-Sulfatase

  Catalysed by STScytosol, Golgi apparatusOne of 6 routes

• N-acetylserotoninReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• xanthineReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by SLC22A24, SLC22A8, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

• glycine betaineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A12cytosol, extracellular spaceOne of 5 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• prostaglandin F1Reach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1B1, DHRS1extracellular space, cytosol

• 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)Reach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC22A24, SLC22A8, CHST10inner side of the membrane, outer side of the membrane

• CHEBI:17895Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:18019Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular space

• thiocyanateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 3 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by STS, SLC25A10, FAHcytosol, mitochondrial matrix

• L-glutamineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 3 routes

• 5-hydroxyisourateReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. urate:oxygen oxidoreductase

  Catalysed by SLC22A24, SLC22A8inner side of the membrane, outer side of the membrane, cytosol

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosol

• CHEBI:18095Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular space

• O-octanoyl-(R)-carnitineReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA

  Catalysed by SLC22A24, SLC22A8, CPT2, CRAT and 1 moreinner side of the membrane, outer side of the membraneOne of 3 routes

• N-carbamoyl-beta-alanineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by STS, SLC26A6cytosol, extracellular spaceOne of 2 routes

• 3beta-hydroxy-5-androstene-7,17-dioneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-hydroxyandrost-5-en-17-one + reduced [NADPH--hemoprotein reductase] + O2 = 3beta,7alpha-dihydroxyandrost-5-en-17-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H(+)

  Catalysed by STS, CYP7B1, HSD11B1cytosol

• hydrogen cyanideReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by STS, SLC25A14, SLC25A30, MPST and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (R)-normetanephrineReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, COMT and 1 moreextracellular space, cytosol