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Proteins/UNIPROT:O43529
Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components. Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones..
Function from UniProtKB (O43529), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 5 reference databases · Subject: CHST10 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
15 reactions
4 names
Resolves to: CHST10
3,3'-diiodo-L-thyronine+3'-phospho-5'-adenylyl sulfate3,3'-diiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or UST or CHST10 or SULT4A1 or CHST7 or HS2ST1 or CHST9 or GAL3ST2 or NDST3 or SULT1B1 or HS6ST3 or GAL3ST4 and 2 more alternatives
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06829CC BY 4.0Reference data
3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]+3'-phosphoadenylyl sulfate3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68304CC BY 4.0Reference data
17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate+3'-phosphoadenylyl sulfate17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68660CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68664CC BY 4.0Reference data
16alpha,17beta-estriol 3-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68668CC BY 4.0Reference data
16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68672CC BY 4.0Reference data
estrone 3-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfateestrone 3-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68676CC BY 4.0Reference data
3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68680CC BY 4.0Reference data
testosterone 17-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfatetestosterone 17-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68684CC BY 4.0Reference data
3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68688CC BY 4.0Reference data
3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68692CC BY 4.0Reference data