2-oxo-3-sulfanylpropanoate

1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

Catalysed by MPST, SQOR

1. L-Cysteine:2-oxoglutarate aminotransferase
2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

Catalysed by GOT2, GOT1, NAGScytosol, mitochondrial matrix

1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

Catalysed by AADAT, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

Catalysed by GOT2, GOT1, SLC1A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

Catalysed by GOT2, GOT1, CARS1cytosol

1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

Catalysed by MPST, SUMF1

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of chloride and cysteine (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC6A14cytosol, extracellular spaceOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. transport of acetate and pyruvate (cytosol to extracellular)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. transport of formate and pyruvate (cytosol to extracellular)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. transport of propanoate and pyruvate (cytosol to extracellular)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. transport of butyrate and pyruvate (cytosol to extracellular)

Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. L-Serine:pyruvate aminotransferase

Catalysed by MPST, TST, AGXTcytosolOne of 2 routes

1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

Catalysed by AADAT, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

Catalysed by MPST, TST, AGXT2cytosol

1. L-Cysteine:2-oxoglutarate aminotransferase
2. De novo synthesis of 2Fe2S

Catalysed by GOT2, GOT1, NDUFAB1, FDXR and 5 morecytosol, mitochondrial matrix

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. D-serine = pyruvate + NH4(+)

Catalysed by MPST, TST, SRRcytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. (R)-Lactate:NAD+ oxidoreductase

Catalysed by MPST, TST, LDHDcytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. (S)-Lactate:NAD+ oxidoreductase

Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. 2-iminopropanoate + H2O = pyruvate + NH4(+)

Catalysed by MPST, TST, RIDAcytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. pyruvate kinase (dTDP)

Catalysed by MPST, TST, PKM, PKLRcytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

Catalysed by MPST, TST, NPLcytosol

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of cysteine and ornithine (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC7A6cytosol, extracellular spaceOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Catalysed by MPST, TST, FAHD1cytosol

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of cysteine and glycine (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 1 morecytosol, extracellular spaceOne of 4 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

Catalysed by MPST, TST, AGXT2cytosol

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of cysteine and methionine (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular spaceOne of 7 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of cysteine and tryptophan (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular spaceOne of 4 routes

1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by MPST, TSTD1

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of alanine and cysteine (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular spaceOne of 32 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of asparagine and cysteine (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular spaceOne of 4 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of cysteine and phenylalanine (cytosol to extracellular)

Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular spaceOne of 6 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

Catalysed by GOT2, GOT1, GCLC, GCLMcytosolOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Catalysed by MPST, TST, TSTD1cytosol

1. L-Cysteine:2-oxoglutarate aminotransferase
2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

Catalysed by GOT2, GOT1, CARS2cytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

Catalysed by MPST, TST, CLYBLcytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

Catalysed by MPST, TST, AGXT2cytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. thiosulfate + glutathione = S-sulfanylglutathione + sulfite + H(+)

Catalysed by MPST, TST, TSTD1cytosolOne of 4 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. (R)-4'-phosphopantothenate:L-cysteine ligase

Catalysed by GOT2, GOT1, PPCScytosolOne of 4 routes

1. L-Cysteine:2-oxoglutarate aminotransferase
2. L-Cysteine:oxygen oxidoreductase

Catalysed by GOT2, GOT1, CDO1cytosolOne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by MPST, TST, HOGA1cytosol

1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

Catalysed by MPST, SQOROne of 2 routes

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Catalysed by MPST, TST, HOGA1cytosol

1. L-Cysteine:2-oxoglutarate aminotransferase
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by GOT2, GOT1, MOCOScytosol

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

Catalysed by MPST, TST, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix

1. L-Cysteine:2-oxoglutarate aminotransferase
2. transport of cysteine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by GOT2, GOT1, SLC7A5cytosol, extracellular space

1. 3-mercaptopyruvate:sulfide sulfurtransferase
2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
3. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Catalysed by