dihydroxyacetone phosphate

Three steps

• 3-hydroxypyruvateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by TPI1, AGXTcytosol

• aceneuramateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by TPI1, NPLcytosol

• 5'-deoxyadenosineReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by TPI1, TYW1B, TYW1cytosol

• hexadecanalReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by GNPAT, ALDH3B1, ALDH3B2, ALDH3A2peroxisome, cytosolOne of 3 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by GNPAT, AGPS, RPE65

• glycerolReach from here →
  1. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  2. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)
  3. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)

  Catalysed by TPI1, TKFC, AKR1A1, AKR1B1

• CHEBI:17808Reach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)
  3. ITP:D-fructose 6-phosphotransferase

  Catalysed by ALDOB, KHK, HK1, HK2 and 2 morecytosol

• D-glucitolReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)
  3. D-Glucitol:NAD+ 2-oxidoreductase

  Catalysed by ALDOB, KHK, SORDcytosol

• sucroseReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)
  3. sucrose + H2O = beta-D-fructose + alpha-D-glucose

  Catalysed by ALDOB, KHK, SI

• dTDPReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by TPI1, PKM, PKLRcytosol

• keto-D-fructose 1-phosphateReach from here →
  1. dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)
  2. Glycerone phosphate phosphohydrolase
  3. D-fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase

  Catalysed by TKFC, ALPL, ALPP, ALPI and 4 moreextracellular space, cytosolOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by TPI1, AGXT2cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by TPI1, AGXT2cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by TPI1, AGXT2cytosol

• S-hexadecanoyl-N-acetylcysteamineReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)

  Catalysed by GNPAT, AGPS, PPT1, PPT2

• S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by GNPAT, AGPS, PPT1

• octadecanoateReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  3. Fas180

  Catalysed by GNPATperoxisome, cytosol

• CHEBI:29052Reach from here →
  1. dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)
  2. Glycerone phosphate phosphohydrolase
  3. D-glyceraldehyde-3-phosphate aldose-ketose-isomerase

  Catalysed by TKFC, ALPL, ALPP, ALPI and 2 moreextracellular space, cytosolOne of 4 routes

• acetateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by TPI1, SLC16A4, SLC16A5, SLC16A3 and 2 morecytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by TPI1, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by TPI1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by TPI1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by TPI1, AGXTcytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by TPI1, AGXT2cytosol

• D-serineReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by TPI1, SRRcytosol

• fatty acidReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosolOne of 4 routes

• (R)-lactic acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-Lactoylglutathione hydrolase

  Catalysed by TPI1, GLO1, GLOD4, HAGH and 1 morecytosolOne of 5 routes

• (S)-lactic acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by TPI1, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes

• 2-iminopropanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by TPI1, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. pyruvate kinase (dTDP)

  Catalysed by TPI1, PKM, PKLRcytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by TPI1, NPLcytosol

• 16-hydroxyhexadecanoateReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by GNPAT, CYP4F2, CYP4F3peroxisome, endoplasmic reticulumOne of 3 routes

• 2-deoxy-alpha-D-ribose 1-phosphateReach from here →
  1. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  2. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  3. 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

  Catalysed by TPI1, DERA, PGM2

• a 3-acylpyruvateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by TPI1, FAHD1cytosol

• hexadecanoyl-CoAReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  3. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate

  Catalysed by GNPAT, AGPS, SLC27A2, ACSL4 and 9 more

• D-sedoheptulose 7-phosphateReach from here →
  1. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
  2. beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate
  3. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

  Catalysed by ALDOA, ALDOB, ALDOC, FBP2 and 2 moreOne of 3 routes

• sn-glycerol 3-phosphateReach from here →
  1. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)

  Catalysed by GNPAT, DHRS7B, LYPLA2, PNPLA7 and 1 more

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by TPI1, MPSTcytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by TPI1, AGXT2cytosol

• L-methionineReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by TPI1, TYW1B, TYW1cytosol

• glutathioneReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by TPI1, GLO1, GLOD4, HAGHcytosol

• L-alanineReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by TPI1, AGXT2cytosol, mitochondrial matrixOne of 18 routes

• a 1-O-alkyl-sn-glycero-3-phosphateReach from here →
  1. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
  2. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)
  3. a 1-O-alkylglycerone 3-phosphate + NADPH + H(+) = a 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)

  Catalysed by GNPAT, AGPS, DHRS7B

• alpha-D-glucose 6-phosphateReach from here →
  1. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
  2. beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate
  3. alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate

  Catalysed by ALDOA, ALDOB, ALDOC, FBP2 and 2 more

• (2R)-3-phosphoglycerateReach from here →
  1. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  2. D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)
  3. ATP:3-phospho-D-glycerate 1-phosphotransferase

  Catalysed by TPI1, GAPDHS, GAPDH, PGK1 and 2 morecytosolOne of 9 routes

• alpha-D-glucose 1,6-bisphosphateReach from here →
  1. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  2. D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)
  3. 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase

  Catalysed by TPI1, GAPDHS, GAPDH, PGM2L1cytosolOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by TPI1, CLYBLcytosol

• 5-amino-2-oxopentanoateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by TPI1, AGXT2cytosol

• D-fructose 6-phosphateReach from here →
  1. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  2. beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate
  3. D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)

  Catalysed by ALDOB, IMPA1, DCPH1, HK1 and 3 more

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. dihydroxyacetone phosphate = methylglyoxal + phosphate
  2. 2-Oxopropanal:NADP+ oxidoreductase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by TPI1, HOGA1cytosol